Expression of TLR10 in B-cell subsets correlates with Primary Sj?gren's Syndrome progression

【摘要】：Primary Sjogren's Syndrome(pSS) is considered a B cell-mediated disease,yet the precise role of B cells in the pathogenesis is not fully understood.TLR10 is highly expressed in B cells,indicating that TLR10 probably plays a vital role in the progression of B cell-related diseases.However,the biology of TLR10 in pSS is less researched.Here,we detected the expression of TLR10 in peripheral B cell subsets from pSS patients and healthy controls(HCs) and further analyzed the correlations of TLR10 expression with disease activity.We observed that TLR10 expression in peripheral CD19~+B cells and CD19~+CD27~+lgD~-switched memory B cells was significantly increased in the low activity pSS patients as compared with the HCs and high activity pSS patients.TLR10 expression in CD19~+B cells and switched memory B cells in pSS patients was significantly negatively correlated with anti-SSA antibody and BAFF production.Moreover,the TLR10 high-expressed pSS patients presented with decreased percentage of switched memory B cells and very low proportion of high-activity pSS patients,as compared with the TLR10 low-expressed pSS patients.Our study concluded that TLR10 expression in CD19~+B cells and switched memory B is negatively correlated with pSS disease activity and TLR10 might suppress pSS progression via inhibiting B cell function.These results should contribute to the diagnosis and treatment of pSS.