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Human neutralizing antibodies isolated from a Zika patient and their molecular determinants

Wang Qihui  Yang Huabing  Liu Xiaoqing  Dai Lianpan  Ma Tong  Qi Jianxun  Wong Gary  Peng Ruchao  Liu Sheng  Li Junfu  Li Shihua  Song Jian  Liu Jianying  He Jianhua  Yuan Hui  Xiong Ying  Liao Yong  Li Jianhua  Yang Jianping  Tong Zhou  Griffin Bryan  Bi Yuhai  Liang Mifang  Xu Xiaoning  Qin Chuan  Cheng Gong  Wang Peiyi  Qiu Xiangguo  Kobinger Gary  Shi Yi  Yan Jinghua  Gao Fu  
【摘要】:正Zika virus infections are associated with fetal microcephaly,neurological complications and constitute a public health emergency.Herein,we report the isolation of 13 specific,human-origin monoclonal antibodies from an imported Zika case to China.Two of the isolated antibodies(Z23 and Z3L1)demonstrate potent Zika-specific neutralization in vitro without binding or neutralizing activity against Zika’s closest relative Dengue virus(DENV)1-4,

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