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Prognostic value of Bmi-1 expression in human epithelial ovarian cancer

Xu Yun  Chen Lujun  Rui Xiaohui  Xu Bin  Jiang Xiping  Huang Yaqing  Jiang Guohua  Guo Caixia  Shao Yingjie  Li Xiaodong  Zhou You  Zheng Xiao  Jiang Jingting  
【摘要】:Objectives: The aim of this study was to explore the role of Bmi-1 as a prognostic biomarker in epithelial ovarian cancer(EOC). Methods: Bmi-1 expression was assessed in 82 EOC tissues and 10 control tissues using immunochemistry. Statistical analyses were performed to investigate the associations between Bmi-1 expression and clinicopathological characteristics as well as survival time. Results: Positive Bmi-1 expression was detected in 87.8%(72/82) of EOC tissues and significantly higher expression of Bmi-1 was observed in EOC than in benign ovarian tumor tissues(P 0.01).Cox regression analyses revealed that higher Bmi-1 level was significantly associated with poorer overall survival in patients with EOC(mean overall survival, 45.4 vs. 69.3 months) than those with benign ovarian tumors. Moreover, high Bmi-1 expression was an independent predictor for prognosis(HR= 2.212, 95% CI = 1.091-4.482, P 0.05) in EOC patients. This was further confirmed by survival analysis based on Bmi-1 levels from a large patient cohort(1582 cases) derived from The Cancer Genome Atlas(TCGA) and Gene Expression Omnibus(GEO). Conclusions: High Bmi-1 expression is positively associated with metastastic disease and poor prognosis in EOC.

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