The structure,pathogenicity and immunogenicity of two virion fractions harvested from cell cultures infected with the CA16 virus
【摘要】:正The study of Coxsackie virus type A 16(CA16),a major causative agent of hand,foot and mouth disease(HFMD),has suggested that two types of virions could be harvested from cell cultures:a real(R)virion fraction containing complete viral particles and a pseudo(P)virion fraction containing defective particles.To investigate the biological characteristics of the virion