Downregulation of endothelin-1 by somatostatin improves liver function of recipients undergoing adult-to-adult living donor liver transplantation
【摘要】：Background The aim of this study was to investigate the possible effect of somatostatin on the liver function of recipients undergoing living donor liver transplantation. Methods Forty recipients were randomly divided into to group A (n=20) and group B (n=20). Recipients in group A received no somatostatin administration whereas somatostatin was administrated in group B perioperatively. Liver function tests,the plasma concentration of endothelin-1 and nitric oxide,the intragraft expressions of endothelin-1 and inducible nitric oxide syntheses at 2h after declamping of the portal vein were compared between the two groups. Results Compared to group A,alanine transaminase values in group B significantly reduced at 2h after portal vein declamping,at the end of the operation and postoperation day 1 (P0.05),whereas aspartate aminotransferase values in group B decreased at 30 min after portal vein clamping,at 2h after portal vein declamping and at the end of the operation (P0.05). Total bilirubin values in group B reduced statistically significantly at 2h after portal vein declamping and at the end of the operation when compared to group A (P0.05). Intragraft expression of endothelin-1 was significantly downregulated at 2h after declamping of the portal vein accompanied with a reduction of plasma concentration of endothelin-1 in the peripheral blood. Conclusions Somatostatin had a protective effect on liver function during the early phase after declamping of portal vein for recipients undergoing living donor liver transplantation,and the possible mechanism might be partially attributed to the downregulation of endothelin-1.