The interaction between Levofloxacine Hydrochloride and DNA mediated by Cu~(2+)
【摘要】：正Levofloxacin (LEV), is a fluoroquinolone antimicrobial agent. LEV also inhibits DNA synthesis and is bactericidal.The mechanisms of the interaction among LEV, DNA and Cu2+ are studied by fluorescence and UV spectra method. In the paper, the results show that LEV and Cu2+ can form binary complex, and also LEV and DNA can form complex mediated by Cu2+. The composition of the complex is determined. The affects to the reaction are also found.