Mechanics in mechanosensitivity of cell adhesion and its roles in cell migration
【摘要】:正Cells sense and respond to their environment and external stimuli through focal adhesions complexs (FACs) to regulate a broad range of physiological and pathological processes,including cell migration.Currently, the basic principles in mechanics/mechanobiology of the mechanosensitivity of cell adhesion and migration have not yet been fully understood.This talk will be focused on the environment and stimuli dependent properties of cell adhesion and migration.A microscopic model of the FAC is proposed for understanding the responses of cell adhesion to the forces of different magnitudes,in which the FAC is modeled by a molecular clus-