Risk genes are not associated with the age at onset of bipolar disorder

【摘要】：Bipolar disorder has been proved to be a multigenic disease,and genetic factors play an important role in the pathogenesis of this disease.If there is a correlation between the risk genes and the age of onset of bipolar disorder,we can predict the onset age of bipolar disorder individuals by testing genes,so as to improve the early diagnosis and early intervention.To test this hypothesis,we search out 26 SNP sites which have been demonstrated to be associated with bipolar disorder.Then we test these SNPs' genotypes of 224 bipolar disorder patients,and analyzed the correlation between the risk genotypes and the age of onset.The results suggest that there is no significant correlation between these SNP sites and the age at onset in the patients with bipolar disorder(P 0.05).In summary,the study confirmed that bipolar disorder is a multigenic disease,and the single risk gene has no effect on the age of first onset.