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《2013中国器官移植大会论文汇编》2013年
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Immune function assay(ImmuKnow)as a predictor of allograft rejection and infection in kidney transplantation

Jun He  Yang Li  Xuedong Wei  Hao Zhen  Jianquan Hou  
【摘要】:正Background The Cylex Immuknow(IK) assay provides a rapid and quantitative assessment of T-cell-mediated immune function. Studies have shown correlations between Immuknow assay and adverse events,such as immunosuppression and low or high calcineurin inhibitor - trough levels.We investigated the correlation between IK changes and rejection or infection in kidney transplant patients,and studied the potential application of the IK assays in optimizing individual immunosuppressive therapy. Msthods Immuknow assay was used to determine dynamic intracellular ATP changes in CD4 cells in 193 samples from both 42 kidney transplant patients and 25 healthy subjects.Patients were categorized into rejection,infection,and event-free groups.The IK values were assayed and analyzed between kidney transplant patients and healthy controls.

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