Effects of estrogen and testosterone therapy on serum metabolites in postmenopausal women
【摘要】:正Objective To study effects of estrogen and testosterone therapy on serum metabolites in postmenopausal women,and explore possible relationships between the serum metabolites and carbohydrate/lipid metabolism. Methods Sixty naturally postmenopausal women were randomly assigned to treatment with testosterone undecanoate 40 mg every second day(T group);estradiol valerate 2 mg daily(E group);or the combination of both(T+E group). Serum metabolites were determined by gas chromatography-mass spectrometry/time-of-fight(GC/TOF-MS) before and