收藏本站
《2017中国中西医结合麻醉学会[CSIA]年会暨第四届全国中西医结合麻醉学术研讨会暨陕西省中西医结合学会麻醉专业委员会成立大会论文资料汇编》2017年
收藏 | 手机打开
二维码
手机客户端打开本文

Molecular Mechanism Underlying Short-Term Perioperative Stress-Induced Prolongation of Postsurgical Pain

Yuan-Xiang Tao  
【摘要】:We have previously reported that short-term perioperative stress prolonged postoperative pain.However,the molecular mechanisms underlying this prolongation are elusive.We here shown that short-term stress caused by 6 h sleep disturbance daily for 3says significantly reduced the expression of TET1,but not TET2,TET3,DNMT1,DNMT3a and DNMT3b,in the neurons of dorsal root ganglion(DRG)and spinal cord dorsal horn.This reduction is triggered by glucocorticoid receptor activation and contributed to short-term stress-induced downregulation in mu opioid receptor and kappa opioid receptor in the DRG and dorsal horn and prolongation of incisional pain.TET1may be a new potential target for prolonged postoperative pain management.
【作者单位】:Departments of Anesthesiology,Cell Biology & Molecular Medicine,Neurology &Neuroscience,and Physiology & Pharmacology,New Jersey Medical School,Rutgers,The State University of New Jersey
【分类号】:R402
【正文快照】:
Molecular Mechanism Underlying Short-Term Perioperative Stress-Induced Prolongation of Postsurgical Pain@Yuan-Xiang Tao$Departments of Anesthesiology,Cell Biology Molecular Medicine,Neurology Neuroscience,and Physiology Pharmacology,New Jersey Medic

【相似文献】
中国期刊全文数据库 前10条
1 ;Expression of nerve growth factor in spinal dorsal horn following crushed spinal cord injury[J];中国病理生理杂志;2001年08期
2 路来金;宫旭;刘志刚;张志新;;Retrospective study of reverse dorsal metacarpal flap and compound flap: a review of 122 cases[J];Chinese Journal of Traumatology;2006年01期
3 William D.WILLIS;;DIFFERENT EFFECTS OF ACTIVATION OF DIFFERENT PROTEIN KINASES ON THE RESPONSES OF PRIMATE SPINOTHALAMIC TRACT NEURONS TO MECHANICAL STIMULI-IN THE PERIPHERY[J];神经解剖学杂志;2001年S1期
4 ;Neurotoxicity of intrathecal injections of dexmedetomidine into the rat spinal dorsal horn[J];Neural Regeneration Research;2012年23期
5 ;Scanning and transmission electron microscopic observations on the body wall and eggs of Enterobius vermicularis.[J];寄生虫学与寄生虫病杂志;1983年S1期
6 Y.Sato ,S.Uchida ,M.Shimura;Calcitonin gene-related peptide produces skeletal muscle and nerve vasodilation following antidromic stimulation of unmyelinated afferents in the dorsal root in rats[J];上海针灸杂志;2003年11期
7 ;Transcriptional control of GABAergic neuron development in the dorsal spinal cord[J];Journal of Medical Colleges of PLA;2008年03期
8 许亚军;Clinical application of the trifoliated flap from the dorsal foot[J];China Medical Abstracts;2003年02期
9 ;Modulatory effect of substance P on GABA-activated currents from rat dorsal root ganglion[J];Acta Pharmacologica Sinica;2004年05期
10 ;EFFECTS OF DORSAL RAPHE NUCLEUS STIMULATION AND ACUPUNCTURE ON NOXIOUS RESPONSE OF DORSAL HORNNEURONS IN RATS[J];针刺研究;1989年Z1期
中国重要会议论文全文数据库 前10条
1 ;Role of Lmxlb in the formation of somatosensory circuitry in the dorsal spinal cord[A];Proceedings of the 7th Biennial Meeting and the 5th Congress of the Chinese Society for Neuroscience[C];2007年
2 ;Tbx3 and Ptfla determine the expression of receptors of neurotransmitters and nueropeptides in the dorsal spinal cord[A];中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集[C];2011年
3 ;The major histocompatibility complex genes were associated with the painrelated responses induced by formalin between DA and congenic DA.1U rats[A];Proceedings of the 8th Biennial Conference of the Chinese Society for Neuroscience[C];2009年
4 ;Inflammatory pain induced ProBDNF and its receptors expression change in rat spinal dorsal horn[A];中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集[C];2011年
5 徐云扬;李蕙心;;梅县客家话舌面声母之发音研究(英文)[A];第九届中国语音学学术会议论文集[C];2010年
6 ;Modulation by oxytocin of ATP-activated currents in rat dorsal root ganglion neurons[A];中国生理学会第21届全国代表大会暨学术会议论文摘要汇编[C];2002年
7 ;Two distinct vesicle pools for depolarization-induced exocytosis in somata of dorsal root ganglion neurons[A];第九届全国钙信号和细胞功能研讨会论文摘要集[C];2012年
8 Tianwen Huang;Wenlong Zhao;Menggui Huang;Zhen Guo;Jia Hu;Leping Cheng;;Transcriptional control of neurotransmitter phenotypes and their receptors in the developing dorsal spinal cord[A];细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉论文摘要集[C];2013年
9 Peng Xin;Lin Bian;Xue Bai;Zhen Liu;Huaxiang Liu;Zhenzhong Li;;Neurotoxicity of decabromodiphenyl ether on dorsal root ganglion neurons in vitro[A];华东六省一市第22届解剖与组织胚胎学学术年会暨山东解剖学会成立60周年纪念大会论文汇编[C];2013年
10 ;Different distributions of P2X4 and P2X7 receptors in the neurons of the spinal cord dorsal horn of rats with spared nerve injury[A];Proceedings of the 8th Biennial Conference of the Chinese Society for Neuroscience[C];2009年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026