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《首届国际中西医结合风湿病学术会议论文汇编》2004年
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The pharmacodynamics Study on the Treatment of Systemic Lupus Erythematosus with Jin-Gong-Jin-Gao Tablets

【摘要】:正bjective: To explore the pharmacodynamics and action mechanism of the Chinese traditional patent medicine of Jin-Gong-Jin-Gao tablets.Methods: After preparing the autoimmune syndrome animal model of mice,the model mice were gavaged with different doses of Jin-Gong-Jin-Gao tablets.The cell-mediated immunity factor, anti-ssDNA antibody, anti-dsDNA antibody, T cell subgroup,lymphocyte transformation, urine protein changes and the swell degree of metatarsal of foot in the treated mice were used as indexes to observe the pharmacodynamics and action mechanism of Jin-Gong-Jin-Gao tablets.The negtive control group treatd with native salt solution and the positive control with tripterygium wilfordii hook were adopted.Results: In tripterygium wilfordii hook group (100mg/kg/d) and Jin-Gong-Jin-Gao tablets groups (800~1000mg/kg/d), the serum IL-1 and IL-6 level, anti-ssDNA antibody, anti-dsDNA antibody concentrations,L_3L_4~+ level, urine protein and the swell degree of metatarsal of foot reduced markedly, however, the IL-2 level and Lyt-2~+ level increased evidently.Conclusion: Both the middle and high doses of Jin-Gong-Jin-Gao tablets and tripterygium wilfordii hook have strong Immunoregulation and anti-inflammation function. They can also prevent the urine protein from exuding in model mice.
【分类号】:R259

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