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《两岸三地药理学与临床药理学术会议论文集》2008年
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The total flavonoids extracted from Xiaobuxin Tang reverse the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats

【摘要】:正Objective To investigate the effect of XBXT-2 on the activity of hypothalamic-pituitary-adrenal (HPA) axis in chronic mild stress (CMS) model of rats.Methods Using ELISA to test the serum corticos- terone,adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) level in CMS rats;Using western blot to determine hippocampal glucocorticoids receptors (GR) expression in CMS rats. Results Co-administration of XBXT-2 (25,50 mg·kg~(-1),p.o.,28 days,the effective doses for behavioral re- sponses) significantly decreased the serum corticosterone and ACTH level in CMS rats,while the CRH level was not markedly affected by chronic stress or drugs.Moreover,XBXT-2 significantly increased the GR ex- pression in the hippocampus of CMS rats.The same effects were observed in the positive control drug imipramine (10 mg·kg~(-1),p.o.).Conclusions The decrease of serum corticosterone and ACTH level,as well as the increase of hippocampal GR expression may be the mechanisms underlying the antidepressant action of XBXT-2,which may associate with HPA axis.
【分类号】:R285

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