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《中国烟草学会学术年会优秀论文集》2017年
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Antiviral Sesquiterpenes from leaves of Nicotiana tabacum

Shan-Zhai Shang  Wei Zhao  Jian-Guo Tang  Xing-Meng Xu  Han-Dong Sun  Jian-Xin Pu  Zhi-Hua Liu  Ming-Ming Miao  Yong-Kuan Chen  Guang-Yu Yang  
【摘要】:Three unreported sesquiterpenes possessing two new skeletons, tabasesquiterpenes A-C(1-3), together with three known sesquiterpenes(3-6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1 D- and 2 D NMR techniques. Compounds 1-6 were evaluated for their anti-tobacco mosaic virus(anti-TMV) activities. The results showed that compound 2 exhibited high anti-TMV activity with inhibition rate of 35.2%, which were higher than that of positive control(ningnanmycin). The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 20.5 ~ 28.6%, respectively.

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