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《第五届全国人畜共患病学术研讨会论文摘要集》2017年
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Structural and functional insights into pestivirus NS3 protease cis-cleavage and helicase auto-stimulation

Fengwei Zheng  Guoliang Lu  Ling Li  龚鹏  Zishu Pan  
【摘要】:正The nonstructural protein NS3 from the Flaviviridae family is a multi-functional protein that contains an N-terminal protease and a C-terminal helicase,playing essential roles in viral polyprotein processing and genome replication.Here we report a full-length crystal structure of the Classical swine fever virus(CSFV)NS3 at 2.4 A resolution,including the previously unsolved protease module.The structure reveals a medium size intra-molecular interface between the

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