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《第十一届全国钙信号和细胞功能研讨会摘要集》2016年
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Polycystin 2 is required for glucose deprivation induced Autophagy in human embryonic stem cell derived cardiomyocytes

Jun Lu  Xiaoqiang Yao  
【摘要】:Autophagy is a ubiquitous process for protein and organelle recycling, critical to numerous forms of stress responsiveness. The activities of m TOR and AMPK, two major regulators of autophagy, are dysregulated in autosomal dominant polycystic kidney disease(ADPKD) which caused by Polycytin 2(PKD2) mutation. Therefore we hypothesized that PKD2 is possible candidate for autophagy regulation in human embryonic stem cell derived cardiomyocytes(h ESC-CMs). The PKD2 was silenced in h ESC-CMs by sh RNA lentivirus-mediated transduction. Short-term glucose deprivation, which mimicked myocardial ischemia, induced robust accumulation LC3 lipidation in scramble h ESC-CMs. However, this phenomenon was attenuated in cardiomyoytes lacking PKD2. These results demonstrate that PKD2 is a novel regulator of autophagy in h ESC-CMs during glucose deprivation.
【作者单位】:Li Ka Shing Institute of Health Science and School of Biomedical Sciences, The Chinese University of Hong Kong
【分类号】:R329.2
【正文快照】:
Polycystin 2 is required for glucose deprivation induced Autophagy in human embryonic stem cell derived cardiomyocytes@Jun Lu$Li Ka Shing Institute of Health Science and School of Biomedical Sciences, The Chinese University of Hong Kong!Hong Kong, China

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