mTOR enhancement of STIM1-mediated store-operated Ca~(2+) signaling constrains tumor development
【摘要】：正RTK-PI3K-AKT-TSC1/TSC2-mTOR pathway is frequently dysregulated in cancer. Loss-of-function mutations in either the TSCl or TSC2 tumor suppressor gene cause Tuberous Sclerosis Complex(TSC),an autosomal dominant disorder featured with benign tumors in multiple organs.TSC l and TSC2 form a protein complex as a key negative regulator of mTOR.Even though hyperactive mTOR signal ing drives tumor development.the critical effectors downstream of mTOR leading to tumor growth are
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