收藏本站
《中国神经科学学会第十二届全国学术会议论文集》2017年
收藏 | 手机打开
二维码
手机客户端打开本文

Rapid production of new oligodendrocytes is required in the earliest stages of motor skill learning

Lin XIAO  David Ohayon  Ian A.McKenzie  Alexander Sinclair-Wilson  Jordan Wright  Alexander Fudge  Ben Emery  Hui-Liang LI  William D Richardson  
【摘要】:Objective To investigate the possible role of oligodendrocyte in learning. Methods By searching published expression databases, we identified a novel marker of newly-forming oligodendrocytes – the ecto-enzyme Enpp6 – and used this to track oligodendrocyte differentiation in adult mice as they learned a motor skill(running on a complex wheel with unevenly spaced rungs). Results Production of Enpp6-expressing immature oligodendrocytes was accelerated within just 2.5 hours exposure to the complex wheel in subcortical white matter and within 4 hours in motor cortex. Conditional deletion of Myelin regulatory factor(Myrf) in oligodendrocyte precursors blocked formation of new Enpp6+ oligodendrocytes and impaired learning within the same ~2-3 hour time frame. This very early requirement for oligodendrocytes suggests a direct and active role in learning, closely linked to synaptic strengthening. Running performance of normal mice continued to improve over the following week accompanied by secondary waves of oligodendrocyte precursor proliferation and differentiation. Conclusion We conclude that new oligodendrocytes contribute to both early and late stages of motor skill learning.

手机知网App
【相似文献】
中国期刊全文数据库 前5条
1 高煜;;The problems of oral English skill in China[J];科技信息;2011年18期
2 杨丽亚;;Speaking skill Test with Help of Language Lab or Computer[J];科技信息;2010年23期
3 CHO Kyoung-Ho;CHOI Jin-Yong;JEONG Sang-Hun;CHOI Jung-Woon;KWON Jae-Il;PARK Kwang-Soon;;Development of a skill assessment tool for the Korea operational oceanographic system[J];Acta Oceanologica Sinica;2013年09期
4 陈超;;The Differences between Second Language Learning and Skill Learning[J];科技信息(科学教研);2008年21期
5 ;THE ROLE OF TEACHERS IN TEACHING CHINESE AS A FOREIGN LANGUAGE[J];科技信息(学术研究);2007年34期
中国重要会议论文全文数据库 前6条
1 ;THE SELECTED AND OPTIMAL TRAINING TECHNIQUE IN HIGH JUMP[A];第4届全国青年体育科学学术会议论文摘要汇编[C];2005年
2 ;Genetic algorithm combined with immune mechanism and its application in skill fuzzy control[A];2009中国控制与决策会议论文集(3)[C];2009年
3 ;A Cognitive Model with Growing Structure and Its Application to Learning to Control the Inverted Pendulum[A];2009中国控制与决策会议论文集(3)[C];2009年
4 赵贺田;;READ AND THINK FOR EXACT INFORMATION[A];国际交流学院科研论文集(第一期)[C];1994年
5 ;Applying Health Belief Model to Promote Health Education[A];中华护理学会健康教育研讨会暨讲习班论文集[C];2000年
6 Lisa Raphals;;外化德性的比较研究:中国和希腊的表演与竞争(英文)[A];北京论坛(2007)文明的和谐与共同繁荣——人类文明的多元发展模式:“爱智和宏道:人文奥运的哲学基础”哲学分论坛论文或摘要集(上)[C];2007年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026