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《Proceedings of the 7th Biennial Meeting and the 5th Congress of the Chinese Society for Neuroscience》2007年
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Effects and mechanism of electro-acupuncture on the improvement of behaviors in a rat model of Parkinson's disease

【摘要】:正Parkinson's disease(PD) is characterized by degeneration of dopaminergic neurons in substantia nigra pars compacta(SNc).Imbalanced output pathway of basal ganglia is also closely associated with the pathogenesis of Parkinson's disease.Many clinical reports have illustrated the promising result of Electro-acupuncture(EA) in alleviating the sufferings of PD patients.In this study,unilateral transection of the medial forebrain bundle(MFB) was performed using a retractable wire knife to set up the animal model of PD.Different frequencies of chronic EA stimulation(0,2,100 Hz) were tested to analyze their effects on movement behavior of PD rats.Rats were randomly divided into five groups:the sham group,the MFB lesioned group,the three MFB lesioned groups administered respectively with 0 Hz,2 Hz or 100 Hz of EA stimulation..For the EA groups,stimulation was administered from the second day following MFB lesions.Two stainlesssteel needles of were inserted into PD rat obliquely at the acupuncture point DAZHUI and horizontally at BAIHUI. Apomorphine induced rotational behavior test and Rod-test were performed at the last day every week.Twenty-eight days after the lesion,rats were decapitated or perfused for biochemistry detection.The results shows 100 Hz EA stimulation has a definite neuroprotective effect on the dopamine neurons in the substantia nigra;however,it did not increase the DA contents in the striatum.It could also modulate the imbalance of the basal ganglia pathways.The underlying mechanism of improving PD rats' behaviors by 100 Hz EA stimulation may be related to its inhibition of the neuron activities in the output structure of the basal ganglia.
【分类号】:R742.5

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