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Apatinib(YN968D 1) enhances the efficiency of conventional chemotherapeutical drugs by inhibiting P-glycoprotein function in leukemia cells

【摘要】:正Background:P-glycoprotein(P-gp,ABCB1) overexpression and enrichment of stem-like cells have been shown to correlate with poor prognosis in leukemia patients. Methodology/Principal Findings:We investigate the effect of apatinib,an oral small-molecule multi-targeted tyrosine kinase inhibitor(TKI),on the efficiency of conventional anticancer drugs in leukemia side population(SP) cells and ABCB1-,ABCC1/MRP1-,ABCC4/MRP4-,ABCC10/MRP7- and lung resistance protein(LRP)-overexpression cancer cells.Our results show that apatinib significantly enhanced the cytotoxicity of conventional chemotherapeutic drugs in SP

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中国重要会议论文全文数据库 前2条
1 ;Apatinib(YN968D 1) enhances the efficiency of conventional chemotherapeutical drugs by inhibiting P-glycoprotein function in leukemia cells[A];2011医学科学前沿论坛第十二届全国肿瘤药理与化疗学术会议论文集[C];2011年
2 童秀珍;梁树;梁玮;龙冰;李娟;罗绍凯;;Apatinib逆转ABCB1介导的白血病多药耐药作用及机制[A];第13届全国实验血液学会议论文摘要[C];2011年
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