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《第十届全国化学生物学学术会议报告摘要集(女性科学家论坛)》2017年
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Reversible and Quantitative Photoregulation of Target Proteins

Sitao Xie  Liping Qiu  Liang Cui  Honglin Liu  Hao Liang  Ding Ding  Lei He  Huixia Liu  Zhou Chen  Xiaobing Zhang  Weihong Tan  
【摘要】:Essential to elucidating fundamental biological processes is first gaining precise and reversible external control over proteins, but without altering their natural structure. To achieve this goal, we developed an aptamer-based, noninvasive, photoresponsive nanoplatform capable of reversible and quantitative regulation of target protein activity.Protein-specific aptamers equipped with several light-responsive molecules were functionalized onto the surfaces of nanoparticles. By adjusting light irradiation, the light-responsive molecules could drive the conformational switch of aptamer between the blocked status and liberated status. In this way, the target proteins were captured around the nanoparticle or released into the medium, thus leading to respective inhibition or activation of the protein. Moreover, by modulating light irradiation, the protein activity could be quantitatively controlled.

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