收藏本站
《第十届全国化学生物学学术会议报告摘要集(女性科学家论坛)》2017年
收藏 | 手机打开
二维码
手机客户端打开本文

Aptamer-Based DNAAssembly for Detecting Zn2+ and Inhibiting Amyloid β Aggregation

Xiaoxia Hu  Quan Yuan  
【摘要】:Alzheimer ' s disease(AD) is one of the most common age-related neurodegenerative diseases in which abundant amyloid β(Aβ) aggregates come into being neuritic plaques in the brain.[1] In accordance with previous amyloid cascade hypothesis, the aggregation of Aβ in plaques is the primary driving force for AD pathogenesis.[2,3,4] In amyloid neurotoxic plaques, the homeostasis of metal ions,particularly zinc ion(Zn~(2+)), is seriously damaged.[5] Therefore, reasonable design of Zn~(2+)-targeted therapeutic agents is crucial for understanding Zn~(2+)-A β-related neuropathology and for further realization of Zn~(2+)-binding therapy for AD. Herein, we developed a molecular recognition-based DNA assembly for detecting Zn~(2+) around Aβ and further inhibiting Zn~(2+)-mediated Aβ aggregation. The DNA assembly can selectively target A β species and block the surrounding Zn~(2+) due to the specific recognition capability of aptamers. More importantly, this DNA assembly can inhibit the generation of Zn~(2+)-triggered Aβ aggregation due to the trapping of Zn~(2+) around Aβ species. These functions make this molecular recognition-based DNA assembly a promising platform for understanding Zn~(2+)-A β-related neuropathology and manipulating aggregation of A β in AD. Our approach can provide valuable information for studying the Zn~(2+)-A β-related neuropathology and exhibits great potential for AD treatment.
【作者单位】:College of Chemistry and Molecular Sciences, Wuhan University
【分类号】:R749.16;R440

【相似文献】
中国期刊全文数据库 前10条
1 ;Morphology and structural dynamics of amyloid beta 42 assembly in vitro[J];Neural Regeneration Research;2011年05期
2 ;Molecular modeling of the inhibitory mechanism of copper(II) on aggregation of amyloid B-peptide[J];Science in China(Series B:Chemistry);2005年06期
3 ;Molecular dynamics studies of the inhibitory mechanism of copper(Ⅱ) on aggregation of amyloid β-peptide[J];Chinese Chemical Letters;2007年03期
4 N.Satheesh Kumar;N.Nisha;;Phytomedicines as potential inhibitors of β amyloid aggregation: significance to Alzheimer's disease[J];Chinese Journal of Natural Medicines;2014年11期
5 郗文辉;韦广红;;Amyloid-β peptide aggregation and the influence of carbon nanoparticles[J];Chinese Physics B;2016年01期
6 Yuankai Zhu;Hong Zhang;;A Mouse Model of Alzheimer's Disease with Transplanted Stem-Cell-Derived Human Neurons[J];Neuroscience Bulletin;2017年06期
7 ;Abnormal protein aggregation and neurodegenerative diseases[J];Chinese Science Bulletin;2001年01期
8 Qi Qi;Tian-Xin Zhao;Bo-Lin An;Xuan-Yong Liu;Chao Zhong;;Self-assembly and morphological characterization of two-component functional amyloid proteins[J];Chinese Chemical Letters;2017年05期
9 ;Cu(Ⅱ) Potentiation of Alzheimer Aβ1-40 Cytotoxicity and Transition on its Secondary Structure[J];Acta Biochimica et Biophysica Sinica;2006年11期
10 ;Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics[J];Science China(Chemistry);2012年05期
中国重要会议论文全文数据库 前10条
1 Xiaoxia Hu;Quan Yuan;;Aptamer-Based DNAAssembly for Detecting Zn2+ and Inhibiting Amyloid β Aggregation[A];第十届全国化学生物学学术会议报告摘要集(女性科学家论坛)[C];2017年
2 Jun-Ting Yang;Hong-Yan Cai;Meng-Ming Hu;Zhao-Jun Wang;Jun Zhang;Mei-Na Wu;Jin-Shun Qi;;Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1/Tau mouse model[A];中国神经科学学会第十二届全国学术会议论文集[C];2017年
3 Tao Yang;Jian Luo;Liu Yang;Cheng Yao;Xiaohui Wang;;A Multifunctional Fluorescent Chelator for Targeting Metal-Induced Aβ Aggregation[A];中国化学会第九届全国无机化学学术会议论文集——E生物无机化学[C];2015年
4 Keke Wei;Haizhu Jiang;Yuanqiang Hao;Xiuhua Wei;Yintang Zhang;Maotian Xu;;Effect of magnetic field on β-amyloid aggregation by resonance light scattering[A];河南省化学会2016年学术年会论文摘要集[C];2016年
5 An Huang;Xiaofeng Yang;Shuang Li;;Self-assembly amphipathic peptides induce active enzyme aggregation that dramatically increases the operational stability of nitrilase[A];2015中国酶工程与糖生物工程学术研讨会论文摘要集[C];2015年
6 Ben Zhong TANG;;Supramolecular Self-assembly and Circularly Polarized Luminescence of Chiral AIEgens[A];2016年两岸三地高分子液晶态与超分子有序结构学术研讨会(暨第十四届全国高分子液晶态与超分子有序结构学术论文报告会)论文集——大会邀请报告[C];2016年
7 Feng Luo;Xinrui Gui;Dan Li;Xueming Li;Cong Liu;;Atomic structures of amyloid proteins determined by electron diffraction[A];中国晶体学会第六届学术年会暨会员代表大会(大分子晶体学分会)论文摘要集[C];2016年
8 ;Effects of Epitopes Combination and Adjuvants on Immune Responses to Anti-Alzheimer Disease DNA Vaccines[A];中国生物工程学会2006年学术年会暨全国生物反应器学术研讨会论文摘要集[C];2006年
9 李皓然;葛保胜;黄方;;Kinetics study reveals the mechanism of the interaction between Cu(Ⅱ) and Amyloid-β peptides[A];中国化学会-生物物理化学专业委员会第四届全国生物物理化学会议论文集[C];2016年
10 Yi-Ping Chen;Zhi-Shu Huang;Jun Xu;Lian-Quan Gu;;Design, Synthesis and Evaluation of Isoliquiritigenin Derivatives as Potential Dual Inhibitors for Alzheimer Disease[A];2013年中国药学大会暨第十三届中国药师周论文集[C];2013年
中国博士学位论文全文数据库 前3条
1 王博;Amyloid β/RAGE通路上调内质网应激促进主动脉瓣钙化机制的研究[D];华中科技大学;2016年
2 马晶;氟西汀对中老年APP/PS1双转基因AD小鼠的神经保护作用[D];重庆医科大学;2016年
3 张鑫;人胰岛淀粉样多肽的聚集机制研究[D];华中科技大学;2013年
中国硕士学位论文全文数据库 前8条
1 Abdul Basit Bangash;[D];江苏大学;2017年
2 杰克(Bamodu Oluleke);某空气压缩机生产装配规划及虚拟仿真[D];沈阳大学;2013年
3 白琳;肿瘤坏死因子受体在阿尔茨海默病中的变化及其机制探讨[D];青岛大学;2011年
4 赵颖俊;铜相关蛋白CUTA调节BACE1水平和APP的剪切[D];厦门大学;2009年
5 Ajay Pokhrel;[D];昆明医科大学;2015年
6 侯平;铜离子及铜相关蛋白CUTA在APP表达及Aβ生成中的作用研究[D];厦门大学;2014年
7 郑嵋戈;β-淀粉样蛋白和T淋巴细胞相互作用对神经元再生影响的初步研究[D];广东药学院;2011年
8 张珉;未知病变类型脑血管中β-amyloid,α-actin,collagen Ⅳ的免疫组织化学研究[D];中国医科大学;2006年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026