Precision Bionanomaterials Made from Biomacromolecules
【摘要】：Chemical programming of macromolecular structures to instill a set of defined chemical properties designed to behave in a sequential and precise manner is a characteristic vision for creating next generation nanomaterials. In this context, biopolymers such as proteins and nucleic acids provide an attractive platform for the integration of complex chemical design due to their sequence specificity and geometric definition, which allows accurate translation of chemical functionalities to biological activity. We envision that chemically reprogrammed hybrid proteins will bridge the vital link to overcome the limitations of synthetic and biological materials, providing a unique strategy for tailoring precision therapeutics. We are particularly interested in the chemical design of protein-derived hybrid polymers and their supramolecular responsiveness, while summarizing their impact and the advancement in biomedicine. Proteins, in their native form, represent the central framework of all biological processes and are an unrivaled class of macromolecular drugs with immense speci fi city.Whereas in its denatured, unfolded form, protein serves as a monodispersed, biodegradable polymer scaffold decorated with functional side chains available for grafting with molecules of interest. We show that supramolecular interactions facilitated by stimulus responsive chemistry can be intricately designed as a powerful tool to customize protein functions,stability, activity profiles, and transportation capabilities. In addition to proteins, nucleic acids as another class of biomacromolecules have proven extraordinarily useful as a construction material for the fabrication of nanoscale systems. Even large sophisticated nanostructures can be readily constructed by modulating the self-folding of DNA molecules, which is known as DNA origami technology. In this aspect, we have achieved hybrid material combining the programmable properties of DNA and the flexible physical property of polymers which result in unique nanomaterials with precise nanostructure and multifunctionality.