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《第十三届全国量子化学会议报告集》2017年
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A two-photon fluorescent probe for Imaging Human Cytochrome P450 1A: Theoretical Investigation

Chun Zhang  Ai-Min Ren  
【摘要】:Cytochrome P450 1A(CYP1A) is one of the most significant phase I drug-metabolizing enzymes in humans, which plays an important role on the metabolic activation of procarcinogenic compounds to their ultimate carcinogens. Developing efficient methods for rapid detection and real-time monitoring of CYP1 A enzyme activity is considerable significance. Toward this goal, we have firstly designed a 1,8-naphthalimide-based TP fluorescent chromophore NCMN-2(referred synthesized NCMN-1[1]) with large two-photon absorption(TPA) cross section(5190 GM) and separate fluorescence signal before and after recognizing CYP1 A enzyme according to theoretical means.Docking analysis suggested that the designed two-photon probe still could guarantee and achieve the excellent selectivity for CYP1 A enzyme.

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