收藏本站
《第十三届全国量子化学会议报告集》2017年
收藏 | 手机打开
二维码
手机客户端打开本文

Molecular Dynamics Simulations on Barium Blockades in potassium channels

LiDong Gong  Benoit Roux  
【摘要】:Potassium channels are a broad family of membrane proteins present in almost every cell, and their rapid and highly selective conduction of potassium ions across membranes is central to many biological and physiological processes [1,2]. Notably, potassium channel such as KcsA is specifically blocked by the Ba~(2+), which shares a similar size while twice the charge as that of the K+. Translocation of Ba~(2+) towards the extracellular side is further prevented when an ion binds to the "external lock-in" site. A mechanism of Ba~(2+) blocking was proposed by an experiment on the KcsA channel in 2011 [3], and the very recent studies in2014 of the NaK2 K [4] and MthK [5] channels, which share an identical selectivity filter structure as that of KcsA, are making the mechanisms proposed above seems to be even more interesting. To thoroughly explore the Ba~(2+) blocking behavior and provide a comprehensive picture of the key elements to Ba~(2+) binding in potassium channels, in terms of CHARMM 36 force field, we carried a systematic comparison study on Ba~(2+) blockade in the above ion channels.

【相似文献】
中国期刊全文数据库 前10条
1 Zhao Wang;Quanyou Zhang;Ying Yao;Yongzhong Jia;Bingjun Xie;;The extraction of potassium from K-feldspar ore by low temperature molten salt method[J];Chinese Journal of Chemical Engineering;2018年04期
2 ZHAO Xianyin;AN Lianying;LI Chunge;CHENG Li;;The Dissolution Experiment of Polyhalite at Different Temperature and Pressure[J];Acta Geologica Sinica(English Edition);2014年S1期
3 Jian-Hua Chen;Xian-Hao Long;Li-Hong Lan;Qian He;;Thermodynamics and density functional theory study of potassium dichromate interaction with galena[J];International Journal of Minerals Metallurgy and Materials;2014年10期
4 LIU Hong;FENG Qiaoling;ZHANG Wei;XIE Yongjun;LIU Xingguo;;The diagnosis of hyperkalemia induced by potassium chloride in experimental rabbits[J];Journal of Medical Colleges of PLA;2013年02期
5 谢周清;徐思琦;黄宇营;何伟;金嗣昭;孙立广;;Sodium and potassium in the bones of penguin and skua revealed by EPR and SR-XRF technique[J];Chinese Journal of Polar Science;2010年01期
6 ;Chemiluminescence of Luminol-potassium Ferricyanide with Benserazide and Application in Analytical Chemistry[J];Chinese Chemical Letters;2006年09期
7 WONG Henry Tsz-king;;Measurement of Trace Potassium Contaminations With Accelerator Mass Spectrometry[J];Annual Report for China Institute of Atomic Energy;2005年00期
8 ;Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line[J];Chinese Medical Journal;2002年05期
9 蔡子宇;习译扎记[J];上海科技翻译;1988年05期
10 Ebrahim Soroush;Shohreh Shahsavari;Mohammad Mesbah;Mashallah Rezakazemi;Zhi'en Zhang;;A robust predictive tool for estimating CO_2 solubility in potassium based amino acid salt solutions[J];Chinese Journal of Chemical Engineering;2018年04期
中国重要会议论文全文数据库 前10条
1 LiDong Gong;Benoit Roux;;Molecular Dynamics Simulations on Barium Blockades in potassium channels[A];第十三届全国量子化学会议报告集[C];2017年
2 Zili Xie;Jing Feng;Weishan Yang;Zhijian Cao;Zongyun Chen;Yingliang Wu;;Defensins,a novel kind of potassium channel inhibitors[A];第12届生物毒素研究及医药应用学术大会论文集[C];2015年
3 Yang Xiang;Yun Zhang;;Intracellular potassium leakage may directly induce the oligomerization of NLRP3[A];第12届生物毒素研究及医药应用学术大会论文集[C];2015年
4 Chuangeng Zhang;Zili Xie;Xinxin Li;Jing Chen;Yange Lang;Wenxin Li;Zhijian Cao;Yingliang Wu;;Molecular basis for toxin resistance of Mesobuthus martensii voltage-gated potassium channel:insights into potassium channel evolution[A];第12届生物毒素研究及医药应用学术大会论文集[C];2015年
5 Di Cheng;Xiao-fei Li;Huai-xia Yang;;Spectrophotometric determination of pyrogallol using the system of potassium ferricyanide and Fe(Ⅲ)[A];河南省化学会2016年学术年会论文摘要集[C];2016年
6 Yingliang Wu;;Scorpion toxin-potassium channel interactions and their applications[A];中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议论文集——专题报告一[C];2014年
7 ;Role of calcium activated potassium channel in cardioprotection of preconditioning–mechanisms of action[A];中国生理学会第五届全国心血管、呼吸和肾脏生理学学术会议论文摘要汇编[C];2005年
8 Bo Li;Jianping Ouyang;Wenbin Guo;Xinhua Chen;;Proteomic analysis of differential protein expression in Acidithiobacillu ferrooxidans cultivated in high-density potassiumion[A];福建省海洋学会2012年学术年会论文集[C];2013年
9 ;INSTITUTE OF HYDROGEOLOGY AND ENGINEERING GEOLOGY PUBLICATIONS[A];中国地质科学院文集(1982中英文合订本)[C];1985年
10 ;A-type potassium channel mechanism-based diclofenac therapy for bone cancer pain[A];中国生理学会第23届全国会员代表大会暨生理学学术大会论文摘要文集[C];2010年
中国硕士学位论文全文数据库 前2条
1 刘臣;高铁酸钾的制备及其去除水中污染物的初探[D];哈尔滨工业大学;2006年
2 李娜;电压门控性钾通道在三叉神经痛中的作用及外周机制研究[D];第二军医大学;2009年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026