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《全国第十八届大环化学暨第十届超分子化学学术讨论会会议论文集(下)》2016年
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Novel Schiff Base-bridged Quinazolinone Imidazoles:Synthesis, Antimicrobial Activity and Supramolecular Interaction with DNA

方贤富  Hui Wang  周成合  
【摘要】:正A series of novel Schiff base-bridged quinazolinone imidazoles were synthesized and confirmed by NMR and MS spectra.The bioactive assay manifested that most target compounds exhibited good antimicrobial activity.Among them,compound 9i could effectively inhibit the growth of MRSA even superior to reference drugs Chloromycin and Norfloxacin.The
【作者单位】:Key Laboratory of Applied Chemistry of Chongqing Municipality Institute of Bioorganic & Medicinal Chemistry School of Chemistry and Chemical Engineering Southwest University
【基金】:partially supported by the National Natural Science Foundation of China(21372186) the key program from Natural Science Foundation of Chongqing(CSTC2012jjB 10026)
【分类号】:TQ460.1
【正文快照】:
A series of novel Schiff base-bridged quinazolinone imidazoles were synthesized andconfirmed by NMR and MS spectra.The bioactive assay manifested that most target compoundsexhibited good antimicrobial activity.Among them,compound 9i could effectively inh

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