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《全国第十八届大环化学暨第十届超分子化学学术讨论会会议论文集(下)》2016年
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Antimicrobial Berberine Benzimidazoles:Novel DNA Targeting Supramolecular Interaction

Ponmani Jeyakkumar  张玲  Srinivasa Rao Avula  周成合  
【摘要】:正A novel series of DNA targeting antibacterial berberine-benzimidazoles were developed.Compound 5d was found to exhibit good bioactivity against antibacterial and antifungal strains in comparison with Norfloxacin and Fluconazole.Bacterial membrane permeabilization,Gel electrophoresis and Molecular modelling suggested the possible antibacterial mechanism against
【作者单位】:School of Chemistry and Chemical Engineering, Southwest University CSIR-Central Drug Research Institute
【基金】:partially supported by the National Natural Science Foundation of China(No.21172181,21372186) Chongqing Special Foundation for Postdoctoral Research Proposal(Xm2015031)
【分类号】:TQ460.1
【正文快照】:
A novel series of DNA targeting antibacterial berberine-benzimidazoles were developed.Compound 5d was found to exhibit good bioactivity against antibacterial and antifungal strains incomparison with Norfloxacin and Fluconazole.Bacterial membrane permeabi

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