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《中国化学会-生物物理化学专业委员会第四届全国生物物理化学会议论文集》2016年
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Synthesis, characterization and biological activities of a Valen Schiff base and its bismuth(Ⅲ) complex

李旭  李传华  蒋建宏  肖圣雄  李霞  张辉  李强国  
【摘要】:In this work, a new Schiff base ligand [N,N'-bis(2-hydroxy-3-methoxyphenylmethylidene)-2,6-pyridinediamine, C21H19N3O4](abbreviated as H2L,L=C21H17N3O4) and its bismuth(Ⅲ) complex, [Bi(C21H17N3O4)]Cl×2H2O(abbreviated as [Bi(L)]Cl×2H2O) were synthesized in ethanol and THF solvent, respectively. The compositions and structures of two synthetic compounds were characterized by spectrometry(NMR, MS, UV-visible and FT-IR), elemental analysis, chemical analysis, molar conductivity, thermogravimetric analysis and X-ray powder diffraction. The inhibitory activities of the ligand and its bismuth(Ⅲ) complex on the growth of Helicobacter pylori(abbreviated as H. pylori) and Schizosaccharomyces pombe(abbreviated as S. pombe) were studied by microcalorimetry, respectively. The experimental results indicated that the ligand stimulated the growth of H. pylori, while the complex inhibited its growth. By contrast, both the ligand and the complex inhibited the growth of S. pombe, but the inhibitory effect of the complex was stronger than the ligand. In addition, the interaction of the complex and bovine serum albumin(BSA) was investigated by fluorescence spectroscopy. The results revealed that the formation of the complex-BSA led to the fluorescence quenching of BSA. Moreover, The synchronous fluorescence spectra showed the interaction between the complex and BSA could change the microenvironment and conformation of BSA.

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