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《中国化学会第四届有机化学学术会议论文集(下册)》 2005年
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Solvent-free Synthesis of Analogs of Acyclovir using Microwave Irradiation: A Rapid Entry into C-Acyclic Nucleosides Synthesis

【摘要】:正Acyclic nucleosides have been identified as a new class of antiviral agents with a broad spectrum of activity against retroviruses and DNA viruses. Starting from various purine (I) and 2-oxa-l,4-butanediol diacetate (II), ac-etylated analogs of acyclovir (III) are acquired without solvent and catalyst under microwave irradiation in good yields with the reaction time of less than 8 min. Ammonolysis of III by NH3/CH3OH furnishes the analogs of acyclovir (IV). This protocol is an efficient and rapid entry into C-acyclic nucleosides.

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