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《2018环境与健康学术会议--精准环境健康:跨学科合作的挑战论文汇编》2018年
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The association between maternal serum lead level during pregnancy and preterm birth in a Chinese population

Jun Li  Hua Wang  JiaHu Hao  YuanHua Chen  Lu Liu  Zhen Yu  Lin Fu  FangBiao Tao  DeXiang Xu  
【摘要】:Objectives Lead(Pb) is a well-known developmental toxicant.The aim of the present study was to analyze the association between maternal serum Pb level and risk of preterm birth in a population-based birth cohort study.Methods The present study analyzed a sub-study of the China-Anhui Birth Cohort that recruited 3125 eligible mother-and-singleton-offspring pairs.Maternal serum Pb level was measured by graphite furnace atomic absorption spectrometry.All subjects were classified into three groups by tertile division according to serum Pb level:Low-Pb(L-Pb,1.18 μg/dl),Medium-Pb(M-Pb,1.18-1.70 μg/dl),and High-Pb(H-Pb,≥1.71 ug/dl).Results The rate of preterm birth was 2.8%among subjects with L-Pb,6.1%among subjects with M-Pb,and 8.1%among subjects with H-Pb,respectively.After controlling confounding factors,the adjusted OR for preterm birth was 2.33(95%CI:1.49,3.65) among subjects with M-Pb and 3.09(95%CI:2.01,4.76) among subjects with H-Pb.Of interest,maternal Pb exposure in early gestational stage than in middle gestational stage was more susceptible to preterm birth.Moreover,maternal serum Pb level was only associated with increased risk of late preterm birth.Conclusions The present study provides evidence that maternal serum Pb level during pregnancy is positively associated with risk of preterm birth in a Chinese population.

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