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Exposure to Ambient Particulate Air Pollution and Circulating C-reactive Protein Level:A Meta-analysis

Qisijing Liu  Xuelin Gu  Furong Deng  Xinbiao Guo  Shaowei Wu  
【摘要】:Objectives Ambient particulate air pollution is a major threat to the cardiovascular health of the population.Inflammation is an important component of the pathophysiological process linking air pollution and cardiovascular disease(CVD).A classical marker of inflammation—C reactive protein(CRP),has been recognized as an independent predictor of CVD risk.Exposure to ambient particulate matter(PM)may cause systemic inflammatory response but the association with CRP has been inconsistently reported.Methods A systematic literature search of the PubMed,Web of Science,Embase,and Scopus databases for publications up to January 2018 was conducted for studies reporting the association between ambient particulate matter 2.5(PM2.5),particulate matter 10(PM10) and circulating CRP level.We performed meta-analysis for associations reported in individual studies using a random-effect model and evaluated the effect modification by major potential modifiers.Results This meta-analysis comprised data from 41 observational studies with241,186 participants.Long-term exposure to particulate air pollution was more strongly associated with CRP level than short-term exposure.A 10 ug/m3 increase in short-term exposure to PM2.5 and PM10 was associated with increases of 0.79%(95%CI:0.29%,1.29%) and 0.26%(95%CI:-0.02%,0.54%) in CRP level,respectively,and a 10 ug/m3 increase in long-term exposure to PM2.5 and PM10 was associated with much higher increases of 18.49%(95%CI:8.50%,28.49%) and11.10%(95%CI:2.73%,19.46%) in CRP level,respectively.Conclusions Exposure to ambient particulate air pollution is associated with elevated circulating CRP level,suggesting an activated systemic inflammatory state upon exposure which may help explain the association between particulate air pollution and CVD risk.
【作者单位】:Peking University
【分类号】:R12;X513

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