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Mechanisms of Casticin-induced Cytocidal Effects Against the Human Promyelocytic Cell Line HL-60

Bo Yuan  Hidetomo Kikuchi  Eisuke Yuhara  Hideki Hayashi  Norio Takagi  Hiroo Toyoda  
【摘要】:正The effect of casticin was investigated by focusing on cell viability,apoptosis induction and cell cycle arrest in human promyelocytic cell line HL-60.Casticin induced a dose-and time-dependent decrease in cell viability associated with apoptosis induction and G2/M cell cycle arrest.The addition of SB203580,an inhibitor for p38 mitogen-activated protein kinase

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