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Study on Relationship between Metabolism of Cinnamic Acid and Cytochrome P450

【摘要】:Objective:Studied the metabolism of Cinnamic Acid in homogenized liver of rats.To screen the CYP450 enzyme,which participate on metabolism of Cinnamic Acid.And then supply the evidence for rational administration.Methods:The content of Cinnamic Acid in homogenized liver was measured by the reversed phase HPLC.Analysis effects of inductors and inhibitors on metabolism of Cinnamic Acid.Results:The metabolic rate of β-NF group,the specific CYP1A inductor,was higher than control group significantly.But,PB and DEX group,the main CYP2B and CYP3A inductor,respectively,had no significant difference among these and control groups.Further more,α-NF,the CYP1A inhibitor,could inhibit metabolism of Cinnamic Acid significantly.Conclusion:CYP1A is the major enzyme in metabolism of Cinnamic Acid.The medicine,which have induct and inhibit effects on CYP1A,may have interaction with Cinnamic Acid.

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