收藏本站
《第八届全国治疗药物监测学术年会论文摘要集》2018年
收藏 | 手机打开
二维码
手机客户端打开本文

The safety of aripiprazole for tic disordersin children:a systematic review

Chunsong Yang  Zilong Hao  Lingli Zhang  
【摘要】:Background: To assess the safety of aripiprazole for tic disorders(TDs)in children and adolescents.Methods: A systematic literature review was performed in the databases of MEDLINE,Embase, the Cochrane Library and four Chinese databasesfrom inception to June 2017.All types of studies evaluating the safety of aripiprazole for TDs were included.Results: A total 49 studies involving 2520 children were included. The result of meta-analysis of randomized controlled trials showed that there was a significant difference between aripiprazole and haloperidol with respect to rate of somnolence(RR=0.644, 95%CI 0.433-0.958), extrapyramidal symptoms(RR=0.297, 95% CI0.136-0.650), tremor(RR=0.255, 95% CI 0.114-0.571), constipation(RR=0.148, 95%CI0.040-0.553), and dry mouth(RR=0.141, 95% CI0.046-0.425). There was a significant difference between aripiprazole and placebo in the incidence rate of adverse events(AEs) for somnolence(RR=6.565). The meta-analysis of incidence of AEs related to aripiprazole for case series studies revealed that the incidence of sedation was 26.9%, irritability 25%, restlessness 31.3%, nausea and vomiting28.9%, and weight gain 31.3%.Conclusions: Aripiprazole was generally well tolerated in children and adolescents.Common AEs were somnolence, headache, sedation, nausea, and vomiting. Further high-quality studies are needed to confirm the safety of aripiprazole for children and adolescentswith TDs.

免费申请
【相似文献】
中国期刊全文数据库 前10条
1 ;Case Report:Recurrent severe vomiting due to hyperthyroidism[J];Journal of Zhejiang University-Science B(Biomedicine & Biotechnology);2010年03期
2 王中华,陈冬波;Effect of granisetron in preventing vomiting after chemiotherapy[J];中国临床康复;2003年07期
3 崔英,马亦龙,王安宇,许坚,赖少侣,齐锋,李伟,张则;INTERVENTION CHEMOTHERAPY IN COMPREHENSIVE TREATMENT OF ADVANCED NASOPHARYNGEAL CARCINOMA[J];Chinese Journal of Cancer Research;2000年02期
4 赵荣俊;;39 CASES OF MORNING SICKNESS TREATED WITH ACUPUNCTURE[J];Journal of Traditional Chinese Medicine;1987年01期
5 赵长信;;ACUPUNCTURE TREATMENT OF MORNING SICKNESS[J];Journal of Traditional Chinese Medicine;1988年03期
6 王小马;;ELECTROIMPULSE ACUPUNCTURE TREATMENT OF 110 CASES OF ABDOMINAL PAIN AS A SEOUELA OF ABDOMINAL SURGERY[J];Journal of Traditional Chinese Medicine;1988年04期
7 Hui-Ping Wang;Yan-Qiu Huang;Chang-De Jin;;Effects of abdominal massage on gastrointestinal function in ICU patients: a meta-analysis[J];Frontiers of Nursing;2019年04期
8 Xue Zheng;Li Luo;Fu-Gang Han;;Cause of postprandial vomiting-a giant retroperitoneal ganglioneuroma enclosing large blood vessels: A case report[J];World Journal of Clinical Cases;2019年17期
9 张海南,胡治平,蒋波,宋兴旺;Study of acute stroke clinical measuring scale[J];中国临床康复;2002年23期
10 易群,李观荣;CLINICAL TREATMENT OF 121 CASES OF HICCUP CAUSED BY CEREBRAL OPERATION WITH VIBRATION ACUPUNCTURE ON SCALP[J];World Journal of Acupuncture-Moxibustion;1999年03期
中国重要会议论文全文数据库 前10条
1 Chunsong Yang;Zilong Hao;Lingli Zhang;;The safety of aripiprazole for tic disordersin children:a systematic review[A];第八届全国治疗药物监测学术年会论文摘要集[C];2018年
2 ;A Dual Sensing Highly Selective Cyanide Probe Based on Hemithiacyanine Dye[A];中国化学会第28届学术年会第15分会场摘要集[C];2012年
3 高坤;;Diversity of Secondary Metabolites in Vladimiria muliensis[A];第七届全国天然有机化学学术研讨会论文集[C];2008年
4 ;Electroacupoint Stimulation for Postoperative Nausea and Vomiting in Patients Undergoing Supratentorial Craniotomy[A];第十届全国针刺麻醉针刺镇痛及针刺调整效应学术研讨会论文集[C];2010年
5 Hongda Li;Bingzhu Yin;;A highly selective colorimetric and turn-on fluorescent probe for cyanide anion[A];全国第十六届大环化学暨第八届超分子化学学术讨论会论文摘要集[C];2012年
6 ;Laparoscopic Resection of Ectopic Pancreas in the Gastric Antrum: Case Report and Literature Review[A];第十七届中国内镜医师大会论文集[C];2007年
7 王建光;倪育飞;;中西医防治术后恶心呕吐的研究进展[A];2005年浙江省麻醉学学术年会论文汇编[C];2005年
8 Niu Li;Juan Li;Yu Ding;Tingting Yu;Yongnian Shen;Qihua Fu;Yiping Shen;Xiaodong Huang;Jian Wang;;Novel Mutations in the CYP11B2 Gene Causing Aldosterone Synthase Deficiency[A];第十四次全国医学遗传学学术会议论文汇编[C];2015年
9 刘佳;侯炯;;手术后恶心呕吐的研究进展[A];2008年中华医学会全国麻醉学术年会论文汇编[C];2008年
10 刘佳;侯炯;;手术后恶心呕吐的研究进展[A];2008年第七次华东六省一市麻醉学学术会议暨浙江省麻醉学术年会论文汇编(上册)[C];2008年
中国博士学位论文全文数据库 前1条
1 马晓旭;术后恶心呕吐流行病学观察与5-HT3受体基因多态性研究[D];浙江大学;2013年
中国硕士学位论文全文数据库 前10条
1 雷波;昂丹司琼预防腹腔镜胆囊切除术后恶心呕吐的量效观察[D];新疆医科大学;2010年
2 张大良;幽门螺旋杆菌感染与化疗所致恶心、呕吐的关系研究[D];郑州大学;2014年
3 董爽;化疗所致恶心呕吐现状调查[D];华中科技大学;2013年
4 赵冰洁;雷莫司琼联合地塞米松用于预防术后恶心呕吐的临床观察[D];吉林大学;2013年
5 石小云;妇科开腹手术与腹腔镜手术静脉自控镇痛患者术后恶心呕吐的比较[D];华中科技大学;2013年
6 Aseem Madan Khurana;水化联合止吐药物控制顺铂所致迟发性恶心呕吐的试验研究[D];郑州大学;2006年
7 李琦玮;针刺防治恶性肿瘤化疗后恶心呕吐临床研究[D];北京中医药大学;2016年
8 刘勇;术后恶心呕吐危险因素分析[D];新疆医科大学;2008年
9 轩诗进;腹腔镜胆囊切除术后恶心呕吐相关多因素分析的研究[D];山东大学;2005年
10 SUCHI DWIVEDI;[D];昆明医科大学;2013年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026