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《华东地区生物化学与分子生物学学会联合会2017年学术交流会暨安徽省生物化学与分子生物学学会理事会议论文集》2017年
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Personal regulome dynamics of cutaneous T cell lymphoma

瞿昆  Lisa C.Zaba  Ansuman T.Satpathy  Paul G.Giresi  Rui Li  Yonghao Jin  Randall Armstrong  Chen Jin  Nathalie Schmitt  Ziba Rahbar  Hideki Ueno  William J.Greenleaf  Youn H.Kim  Howard Y.Chang  
【摘要】:Here,we define the landscape and dynamics of active regulatory DNA in cutaneous T cell lymphoma(CTCL) by ATAC-seq.Analysis of 111 human CTCL and control samples revealed extensive chromatin signatures that distinguished leukemic,host,and normal CD4+ T cells.We identify three dominant patterns of transcription factor(TF) activation that drive leukemia regulomes,as well as TF deactivations that alter host T cells in CTCL patients.Clinical response to histone deacetylase inhibitors(HDACi) is strongly associated with a concurrent gain in chromatin accessibility.HDACi causes distinct chromatin responses in leukemic and host CD4~+ T cells,reprogramming host T cells toward normalcy.These results provide a foundational framework to study personal regulomes in human cancer and epigenetic therapy.
【作者单位】:中国科学技术大学生命科学院
【分类号】:R739.5

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