收藏本站
《2015年全国睡眠呼吸学术年会论文汇编》2015年
收藏 | 手机打开
二维码
手机客户端打开本文

Obstructive sleep apnea exacerbates airway inflammation in patientswith chronic obstructive pulmonary disease

Yeya Wang  Ke Hu  Kun Liu  Ze Li  Jun Yang  Yan Dong  MeilingNie  Junwen Chen  YushuRuan  Jing Kang  
【摘要】:Background:Chronic obstructive pulmonary disease(COPD)concomitant with obstructive sleep apnea(OSA)is known as overlap syndrome.It has an increased rate of hospitalization due to COPD exacerbationwhich is believed to indicate a worsening of the underlying chronic airway inflammation.Therefore,the aim of this prospective study was to explore whether OSA exacerbates airway inflammation in subjectswith COPD by examining the bronchoalveolar lavage(BAL)fluid.Methods:This prospective study included 47 patients with overlap syndrome and 28 patients withmoderate-to-severe stage stable COPD.Twenty-five patients with overlap syndrome adhered to the continuouspositive airway pressure(CPAP)treatment;the remaining patients either refused CPAP treatmentor discontinued it within 2 weeks owing to adverse effects or other reasons.BAL fluid was collected fromall subjects for the evaluation of cell numbers and tumor necrosis factor alpha(TNFα)and interleukin-8(IL-8)levels.Results:The BAL fluid of patients with overlap syndrome showed a significantly increased proportionof neutrophils and higher TNFαconcentration and IL-8 levels than that of COPD patients;however,theserum CRP levels were not significantly different.An association was found between the percentage ofheutrophils and the TNFαconcentration and IL-8 levels.Moreover,the TNF a concentration was significantlycorrelated with the percentage of nighttime spent with oxygen saturation less than 90%.After CPAPtreatment,airway inflammation was found to decrease significantly.Conclusions:OSA exacerbates airway inflammation in COPD patients.CPAP treatment can improve nocturnalhypoxemia and decrease airway inflammation.
【分类号】:R766;R563.9

手机知网App
【相似文献】
中国期刊全文数据库 前10条
1 ;Effect of vascular endothelial growth factor and its receptor KDR on human airway smooth muscle cells proliferation[J];Chinese Medical Journal;2005年07期
2 张立强,黄席珍,李学旺,吴全有;Alterations in renal function in patients with obstructive sleep apnea syndrome and effects of continuous positive airway pressure[J];Chinese Medical Journal;1997年12期
3 许淑云,徐永健,张珍祥,倪望,陈士新;Contribution of protein kinase C to passively sensitized human airway smooth muscle cells proliferation[J];Chinese Medical Journal;2004年01期
4 张希龙,殷凯生,毛辉,王虹,杨玉;Effect of continuous positive airway pressure treatment on vascular endothelial function in patients with obstructive sleep apnea hypopnea syndrome and coronary artery disease[J];Chinese Medical Journal;2004年06期
5 厐亚敏;;A study on the relevance of airway inflammatory indices in induced sputum and airway hyperresponsiveness in asthmatics[J];China Medical Abstracts(Internal Medicine);2006年04期
6 Francois Herrmann;Jean-Paul Janssens;;Comparison of airway resistance measurements by the forced oscillation technique and the interrupter technique for detecting chronic obstructive pulmonary disease in elderly patients[J];Chinese Medical Journal;2005年22期
7 ;The role of potassium channels in the nitric oxide-induced relaxation of human airway smooth muscle of passively sensitization by serum from allergic asthmatic patients[J];Journal of Nanjing Medical University;2006年03期
8 Wei Liao;Yan Wang;Fang Zhang;Congmin Zhao;;Induction of human β-defensin-2 in airway epithelial cells by Streptococcus pneumoniae:involvement of IP3-dependent intracellular calcium release and NF-jB[J];Chinese Science Bulletin;2014年16期
9 ;Relationship among bacterial colonization,airway inflam-mation, and bronchodilator response in patients with stable chronic obstructive pulmonary disease[J];Chinese Medical Journal;2006年08期
10 李雯,徐永健,张珍祥;Activity of Matrix Metalloproteinase in Airway Epithelial Cells of COPD Patients[J];华中科技大学学报(医学英德文版);2005年02期
中国重要会议论文全文数据库 前10条
1 ;Transforming growth factor-β1 regulates store-operated Ca2+ entry and growth of airway smooth muscle cells[A];中华医学会呼吸病学年会——2011(第十二次全国呼吸病学学术会议)论文汇编[C];2011年
2 Muqing Yu;Xiansheng Liu;Jianmiao Wang;Yongjian Xu;;CD8+ Tc-lymphocytes immunodeviation in peripheral blood and airway from patients of chronic obstructive pulmonary disease and changes after short-term smoking cessation[A];中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议论文汇编[C];2013年
3 ;SHP2 deletion in airway epithelium reduces allergen induced the airway hyperresponsiveness[A];中华医学会呼吸病学年会——2011(第十二次全国呼吸病学学术会议)论文汇编[C];2011年
4 ;The Role of Intelectin in Allergic Airway Inflammation[A];中华医学会第七届全国哮喘学术会议暨中国哮喘联盟第三次大会论文汇编[C];2010年
5 ;SHP2 deletion in airway epithelium reduces allergen induced the airway hyperresponsiveness[A];2011年第三十三届浙江省呼吸系病学术年会暨呼吸疾病诊治新进展学习班论文汇编[C];2011年
6 Jiesen Zhou;Wen Hua;Yingfang Wu;Hongbin Zhou;Wen Li;Huahao Shen;Zhihua Chen;;Autophagy regulates mucin expression in chronic airway inflammation[A];中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议论文汇编[C];2013年
7 ;Effects of Vaccae on airway inflammation and Th1/Th2 ratio changes in sensitized mice[A];浙江省生理科学会2008年学术年会论文汇编[C];2008年
8 ;Muscarinic M3 Receptor Antagonist Bencycloquidium Bromide Attenuates Asthma in Mice[A];第十届全国抗炎免疫药理学学术会议论文集[C];2010年
9 M.Zhang;Kai.WANG;;Enhanced local Foxp3 expression in lung tissue attenuates airway inflammation in a mouse model of asthma[A];华东地区第13届中青年呼吸论坛论文集[C];2012年
10 ;PPARγ agonist modulates GATA-3 and T-bet mRNA transcripts and inhibits allergic airway inflammation in a murine model[A];浙江省中西医结合呼吸病诊治进展暨第六次学术年会论文汇编[C];2008年
中国硕士学位论文全文数据库 前1条
1 李彩娥;多方法综合评估药物干预对哮喘的控制[D];山西医科大学;2012年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026