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《2015年全国睡眠呼吸学术年会论文汇编》2015年
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Chronic intermittent hypoxia versus continuous hypoxia:same effects on hemorheology?

Jing Kang  Yuanyuan Li  Ke Hu  Wen Lu  Xiufang Zhou  Shuhui Yu  Lifang Xu  
【摘要】:Although both chronic intermittent hypoxia(CIH)and chronic continuous hypoxia(CCH)have effects on hemorheology,we do not know whether their roles are the same.In this study,we explored the effect of simulated-apneaCIH on hemorheology in experimental rats and compared with the effect of CCH.45adult SD rats were randomly divided into the normoxic control group,CCHand CIHgroups.CIH rats were given nitrogen and air alternately for 8 hours per day and the experiment lasted for 5 weeks.The control group were placed in the normoxia animal chambers,and the CCH rats were housed in the same chambers which were continuously given normobaric hypoxia(FiO2=10%).After the preparations,the blood samples were taken andthe hemorheology were determined.Compared with control group,the whole blood apparent viscosity,plasma viscosity,hematocrit,erythrocyte aggregation index and electrophoresisindex,platelet aggregation rate and fibrinogensignificantly increased in CIH group and CCHgroup.The whole blood viscosity,plasma viscosity,hematocrit and fibrinogen values were much higher in CCH group than in CIH group.However,there was not significantly difference in RBC deformation index or rigidity index among the three groups and no significantly differenceswere found in the effects on RBC rheological property between CIH and CCH.Our results suggest that intermittent hypoxia and continuous hypoxia increasewhole blood viscosity,impair the functions of red blood cells and promote the platelet aggregation in model rats.Moreover,CCH had a greatereffect on blood rheology than CIH.
【分类号】:R364.4

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