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《中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”论文集》2017年
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The Construction of Three Kinds of Cleft Lip and Palate Models by surgery

Zebiao Zhang  Jianhui Li  Lu Zhang  Chunyi Guan  Hongfei Xia  
【摘要】:Objectives:This study aims at providing important technical assurance and theoretical basis for facial deformity surgery,drug intervention and biomaterial repair so on by simulating the pathologic features of congenital cleft lip and palate,building three kinds of animal models belonging to the category of cleft lip and palate disease.In addition,this study simulated several common characterizations of cleft palate and explored the exsisting advantages and disadvantages of various model constructions to provide a guiding principle of modeling for future researchers in this area.Methods:By performing surgery on 24 Japanese rabbits aged 3-4 weeks,three different models Cleft palate,Alveolar cleft and Palatine process cleft were built.Then,the skull specimens and trauma measurements at different experimental periods were established to evaluate the feasibility of our model construction.Results:After surgery,because of bone defect,the nasal cavity and mouth of the animals in experimental group are connected.And the animals were choked with the water flowed out of the nasal cavity,but there was no danger of their lives.Eight weeks leter,taking and observing a piece of issue from operative area of the experimental animal,the regeneration of the muscularis mucosae occured,but scar tissue was formed.Besides,a large number of bone tissue was lost at the site of resection and there was no excessive regeneration of irregular bone tissue at the site of fracture.The results showed that three standardized cleft palate and alveolar cleft models were correctly obtained.Conclusions:The modeling technique in this experiment is satisfactory for the establishment of cleft palate and alveolar cleft models in different sites and properties.It has the advantages of convenient method,specific cracked parts and standardization of the degree of cracking.So,it can provide an important basis for exploring the repairing mechanism of cleft lip,cleft palate,alveolar cleft and the clinical treatment of craniofacial deformity.It also can provide a standardized modeling scheme for the combination of biological materials and drug therapy in the future.
【作者单位】:Reproductive and Genetic Center of National Research Institute for Family Planning Peking Union Medical College
【分类号】:R-332;R782.2
【正文快照】:
The Construction of Three Kinds of Cleft Lip and Palate Models by surgery@Zebiao Zhang$Reproductive and Genetic Center of National Research Institute for Family Planning Peking Union Medical College @Jianhui Li$Reproductive and Genetic Center of Nation

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