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Expression and clinical significance of LOXL1 and LOXL2 genes in malignant pleural mesothelioma

Wei Xiong  Bin Li  Na Yang  Yuanqian Pu  Zhengliang Li  
【摘要】:Objective: The differences in the expression of lysyl oxidase-like protein 1(LOXL1) and lysyl oxidaselike protein 2(LOXL2) in malignant pleural mesothelioma(MPM) and its prognostic value are still unclear. This article aims to explore the mRNA expression of LOXL1 and LOXL2 genes in MPM tissues and their prognostic significance.Methods: RT-qPCR was used to detect the mRNA expression of LOXL1 and LOXL2 genes in 12 cases of MPM tissues and matched normal pleural tissues. The differences in the expression of LOXL1 and LOXL2 genes in non-tumor tissues and MPM tissues were analyzed through the Oncomine database.The correlation between the mRNA expression of LOXL1 and LOXL2 genes in the TCGA database and the clinicopathological characteristics of MPM was analyzed by R software. A Kaplan-Meier model was constructed to investigate the effects of LOXL1 and LOXL2 mRNA expression on the prognosis of MPM patients. Gene expression profiling interactive analysis(GEPIA) was used to analyze the correlation between LOXL1 and LOXL2 and the expression of MPM tumor marker genes and other members of the LOX family.Results: RT-qPCR detection showed that the expression of LOXL1 and LOXL2 mRNA in MPM tissue was significantly increased compared with matched normal pleural tissue. The expression of LOXL2 gene is correlated with the cancer types of MPM patients. The high expression of LOXL1 and LOXL2 genes and tumor types are independent factors leading to poor prognosis of MPM patients. LOXL1 gene expression has a significant correlation with EFEMP1, MSLN, CALB2, THBS2 and CDH11 gene expression; LOXL2 gene expression has a significant correlation with MSLN, CALB2, THBS2 and CDH11 gene expression. In addition, LOXL1 gene and LOXL2, LOXL4 gene expression are significantly positively correlated. LOXL2 gene expression was significantly positively correlated with LOX, LOXL1 and LOXL4 gene expression.Conclusion: LOXL1 and LOXL2 genes are significantly high expression in MPM tissues, and their gene expression is an effective indicator for evaluating the prognosis of MPM patients.

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