收藏本站
收藏 | 手机打开
二维码
手机客户端打开本文

FOXA1 Reprograms the TGF-β-Stimulated Transcriptional Program from a Metastasis Promoter to a Tumor Suppressor in Nasopharyngeal Carcinoma

Junjun Li  Wei Wang  Mei Yi  Shengnan Chen  Jing Cai  Yuanyuan Ban  Qian Peng  Yin Zhou  Zhaoyang Zeng  Xiaoling Li  Wei Xiong  Guiyuan Li  Bo Xiang  
【摘要】:Nasopharyngeal carcinoma(NPC) is a unique subtype of head and neck squamous carcinoma that is notorious for its high metastatic potential. In this study, we reported that FOXA1 protein was decreased in NPC cells. Loss of FOXA1 is associated with lymph node metastasis and poor prognosis. Silencing FOXA1 in NP69 and C666-1 NPC cells accelerated cell proliferation and migration, while re-expression of FOXA1 has opposite effects. Microarray and RNA-seq analysis revealed that re-expression of FOXA1 in NPC cells reprogrammed the TGF-β-stimulated transcription program, which is characterized by promotion of TGF-β-inducible tumor-suppressive targets but repression of TGF-β-inducible oncogenes expression in NPC cells, leading to restoration of NPC cell sensitivity to TGF-β's growth-inhibitory effect. BAMBI, a TGF-β responsive tumor suppressor, was induced by FOXA1 in NPC cells. FOXA1 binding on the BAMBI gene facilitated SMAD2/3 binding to the BAMBI promoter via increasing BAMBI associated H3 K4 me1 and H3 K27 ac modification.Enforced expression of BAMBI in NPC cells suppressed cell proliferation and invasiveness. Our data suggested that FOXA1 is a master factor in controlling the TGF-β-stimulated transcriptome and a regulator of TGF-β biological functions in NPC oncogenesis.

知网文化
【相似文献】
中国期刊全文数据库 前20条
1 ;Relevant Content[J];Hepatobiliary & Pancreatic Diseases International;2015年04期
2 ;Effects of Phenylacetate on Cell Proliferation and Homeobox Genes Expression in the HCT-8 Colorectal Carcinoma Cell Line[J];Chemical Research in Chinese Universities;2006年02期
3 李瑾,胡国武,欧阳砥,牛瑞芳,周永洽,申泮文;Effect of Cerium on Expression and Activity of MMP-9 from Human Carcinoma of Bladder Cell Line[J];Journal of Rare Earths;2004年02期
4 ;The Inhibitory Effect of Somatostatin Analogue RC-160 on the Growth of Endometrial Carcinoma Cell Line HEC-1A[J];现代妇产科进展;2004年03期
5 郑美蓉,阮幼冰,杨木兰,官阳,武忠弼;The Comparative Study on Ultrastructure and Immunohistochemistry in AFP Negative and Positive Hepatocellular Carcinoma[J];华中科技大学学报(医学英德文版);2004年06期
6 蓝荣芳,刘正湘,宋玉娥,张欣;Effects of rAAV-CD151 and rAAV-antiCD151 on the Migration of Human Tongue Squamous Carcinoma Cell Line Tca8113[J];华中科技大学学报(医学英德文版);2004年06期
7 王少平,陈孝平,张万广,裘法祖;KLF6mRNA Expression in Primary Hepatocellular Carcinoma[J];华中科技大学学报(医学英德文版);2004年06期
8 廖晓锋,易继林,李兴睿,杨志芳,邓巍,田耕;Expression of Angiogenic Factors in Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization[J];华中科技大学学报(医学英德文版);2003年03期
9 张东生,刘璐;Effect of Phosphorus-32 Glass Microspheres on the Human Hepatocellular Carcinoma in Nude Mice[J];Journal of Nanjing Medical University;2002年01期
10 汤钊猷;Treatment of Hepatocellular Carcinoma——Recent Advances and Prospects in the 21~(st)Century[J];肝脏;2002年S1期
11 花宝金,王爱平,侯炜;Clinical Study on Treatment of Mid-Late Stage Gastric Carcinoma by Compound Xiansu Capsule (仙酥胶囊) Combined with Chemotherapy[J];Chinese Journal of Integrated Traditional and Western Medicine;2001年01期
12 程剑华 ,常纲 ,吴万垠 ,刘伟胜 ,杨志钢 ,孟凡喆 ,徐凯 ,李柳宁 ,朱迪盈 ,陈春泳 ,罗海英;Study on Treatment of Primary Hepatic Carcinoma by Arterial Perfusion Embolization with Zedoary Turmeric Oil[J];Chinese Journal of Integrated Traditional and Western Medicine;2001年04期
13 ;Determination of Urinary Heparin in Bladder Transitional Cell Carcinoma and Its Clinical Significance[J];Journal of Nanjing Medical University;2000年01期
14 柴新群,王春友,李勇;The Early Diagnosis and Surgical Treatment of the Gastric Stump Carcinoma[J];华中科技大学学报(医学英德文版);2000年04期
15 刘立思,肖成峰,陶雁玲;Detection and Its Implication of Heat Stress Protein 27 and P21 in Nasopharyngeal Carcinoma[J];华中科技大学学报(医学英德文版);2000年04期
16 ;Effect of Lanthanum Citrate on Two Cell Lines: Human Lung Cancer Cells PG and Human Gastric Carcinoma Cells BGC-823[J];Journal of Rare Earths;2000年02期
17 李辉,张章渝,尚立群,李学昌,王田贵;Carcinoma of the lung and multiple primary tumors[J];Chinese Medical Journal;2000年09期
18 辛彦,王艳萍,张素敏,吴东瑛,徐蕾,张荫昌;Relationship Between CD44v6 Expression and Metastatic Potential and Prognosis in Gastric Carcinoma[J];Chinese Medical Sciences Journal;2000年02期
19 郑世曦,武忠弼,阮幼冰,汤健;Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma and Its Relationship to Tumor Growth and Metastasis[J];Journal of Tongji Medical University;1998年01期
20 李小明,胡国栋,刘鹏程;Segmental Embolization by Ethanol Iodized Oil Emulsion for Hepatocellular Carcinoma[J];Journal of Tongji Medical University;1999年02期
中国重要会议论文全文数据库 前10条
1 Li,Ling;Chen,Yuanyuan;Zhuo,Hui;Chen,Juan;Zhang,Tongtong;Yang,Peng;Cui,Quanzhe;Zhao,Lin;Tang,Yan;;Tspan8 is Highly Expressed in Clear Cell Renal Cell Carcinoma and Confers Poor Prognosis[A];2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛论文集[C];2019年
2 wu,min;;Dynamic changes and Early Diagnosis of Serum Markers in the Whole Course of Hepatitis B-Associated Hepatocellular Carcinoma[A];2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛论文集[C];2019年
3 Ye,Yingnan;;Macrophages-induced Long noncoding RNA H19 Up-regulation Triggers and Activates the miR-193b/MAPK1 Axis and Promotes Cell Aggressiveness in Hepatocellular Carcinoma[A];2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛论文集[C];2019年
4 Zhou,Xiaohui;Cui,Wanmeng;Luo,Wenqi;Matskova,Liudmila;Zhou,Xiaoying;;Expression and Prognostic Significance of CDH4 in Renal Cell Carcinoma[A];2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛论文集[C];2019年
5 肖振州;崔兆磊;陈燕;;Diagnostic Efficacy of MicroRNAs as Auxiliary Biomarkers for Nasopharyngeal Carcinoma: A Meta-analysis Study[A];2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛论文集[C];2018年
6 Junjun Li;Wei Wang;Mei Yi;Shengnan Chen;Jing Cai;Yuanyuan Ban;Qian Peng;Yin Zhou;Zhaoyang Zeng;Xiaoling Li;Wei Xiong;Guiyuan Li;Bo Xiang;;FOXA1 Reprograms the TGF-β-Stimulated Transcriptional Program from a Metastasis Promoter to a Tumor Suppressor in Nasopharyngeal Carcinoma[A];2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛论文集[C];2018年
7 Minjie Mao;Xueping Wang;Shuqin Dai;Wanli Liu;;Heat Shock Protein 90α provides an effective and novel diagnosis strategy for Nasopharyngeal Carcinoma[A];2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛论文集[C];2018年
8 姜颖;;Proteome Landscape of Early-Stage Hepatocellular Carcinoma[A];中国生理学会基质生物学专业委员会第四次全国基质生物学学术会议会议手册[C];2019年
9 ;Different b Values on DWI in Differentiating Pancreatic Carcinoma from Chronic Mass-forming Pancreatitis-Initial Results[A];中华医学会第16次全国放射学学术大会论文汇编[C];2009年
10 ;Contrast-Enhanced Ultrasonography Performance of Recurrent Hepatocellular Carcinoma[A];中华医学会第十次全国超声医学学术会议论文汇编[C];2009年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978