收藏本站
收藏 | 手机打开
二维码
手机客户端打开本文

Genome wide association study using direct-to-consumer genetic testing data and online survey approach in Han Chinese participants among WeGene users, a proof-of-concept study

Lizhong Wang  Xiaotian Yao  Gang Chen  
【摘要】:The growing number of genotyped individuals from direct-to-consumer(DTC) genetic testing and the advent of high-throughput phenotyping techniques have rapidly accelerated the accumulation of personal genome data. By using online survey and self-report measures, we were able to rapidly and inexpensively ascertain a large number of participants among DTC genetic testing consumers. To test this proof-of-concept study model in China, we performed a genome-wide association study(GWAS) of 16 self-reported traits in 12,256 Han Chinese individuals among WeGene users. Of these, we identified the most robust and replicated alleles rs671 in ALDH2 in East Asian ancestry populations map to alcohol-related traits("alcohol flush" P = 8.34×10~(-27); "AUDIT section score" P = 1.09×10~(-20); and "amount of daily drink", P = 2.88×10~(-17)). Petaloid toenail, the nail of little toe appears petaloidly exists in many populations of the Han Nationality in North China, was associated with a loci of genome-wide significance at 5 q14 lead by rs988056(P = 9.10×10~(-9) in "left-sided petaloid toenail"; P = 1.31×10~(-8) in "petaloid toenail number" traits) near PITX1, which has been associated with asymmetric lower-limb malformations. No genome-wide significant signals(threshold P 5×10~(-8)) but only some suggestive association(threshold P 1×10~(-5)) were found in the rest traits, probably due to the complex inheritance patterns of these traits and/or the limited sample size of this pilot study. We conclude that conducting a genetic study using responses to an online questionnaire in a large population of DTC genetic testing consumers may represent a cost-effective strategy to investigate various traits in Chinese populations. Our findings will contribute to future studies of non-European populations and serve as a fundamental resource for understanding the genetics and biology underlying human traits.

知网文化
【相似文献】
中国期刊全文数据库 前20条
1 ZHENG LianBin;LI YongLan;XI HuanJiu;YU KeLi;LU ShunHua;SHI Rui;WEN YouFeng;BAO JingPing;ZHANG XingHua;LI YuLing;REN Fu;XU GuoChang;;Statures in Han populations of China[J];Science China(Life Sciences);2015年02期
2 CHEN Jing-chao;HUANG Hong-juan;WEI Shou-hui;ZHANG Chao-xian;HUANG Zhao-feng;;Characterization of glyphosate-resistant goosegrass(Eleusine indica) populations in China[J];Journal of Integrative Agriculture;2015年05期
3 TANG Na;LI Jia-wei;LIU Yong-min;ZHONG Hua;WANG La-mei;HE Fang;;Human cytomegalovirus infection is associated with essential hypertension in the Kazakh and Han Chinese populations[J];中国病理生理杂志;2015年10期
4 乔洪金;刘相全;张锡佳;姜海滨;王际英;张利民;;Genetic diversity of populations and clones of Rhopilema esculentum in China based on AFLP analysis[J];Chinese Journal of Oceanology and Limnology;2013年02期
5 张桂玲;曹媛钰;黎中宝;陈锦;赵斌丽;雷光高;王展林;;Analysis of the genetic diversity and differentiation of Fenneropenaeus penicillatus populations using AFLP technology[J];Chinese Journal of Oceanology and Limnology;2012年03期
6 ;Analysis of genetic variation within and among Ulva pertusa (Ulvaceae,Chlorophyta) populations using ISSR markers[J];Chinese Science Bulletin;2010年08期
7 ;Clonal diversity of Clintonia udensis Trautv.et Mey. populations and its correlation with ecological factors[J];Science in China(Series C:Life Sciences);2008年07期
8 ;Genetic divergence among geographical populations of the migratory locust in China[J];Science in China(Series C:Life Sciences);2005年06期
9 ;The genetic diversity of central and peripheral populations of ratlike hamster (Cricetulus triton)[J];Chinese Science Bulletin;2002年03期
10 ;Application of biomarkers for the identification of health hazards and risk in human populations[J];癌变.畸变.突变;2001年04期
11 肖春杰,L.L.Cavalli-Sforza,E.Minch,杜若甫;Principal component analysis of gene frequencies of Chinese populations[J];Science in China(Series C:Life Sciences);2000年05期
12 ;Distribution of YAP in 10 populations of China[J];Chinese Science Bulletin;1998年12期
13 俞民澍,邱信芳,薛京伦,刘祖洞,谈家桢,李厚均,刘德祥,李力,余伍忠,唐仙珍,周美蓉;MITOCHONDRIAL DNA POLYMORPHISM IN CHINESE[J];Science in China,Ser.B;1988年07期
14 来芳,赵寿元,蒋志凌,刘祖洞,孙晋武;THE DISTRIBUTION OF P ELEMENTS IN D. melanogaster ALONG THE COAST OF CHINA STUDIED BY DNA HYBRIDIZATION METHOD[J];Science in China,Ser.B;1988年05期
15 YANG Fang-yuan;GUO Jian-jun;LIU Ning;ZHANG Run-zhi;;Genetic structure of the invasive Colorado potato beetle Leptinotarsa decemlineata populations in China[J];Journal of Integrative Agriculture;2020年02期
16 邓萍;蒋刚;;Charge-state populations for the neon-XFEL system[J];Chinese Physics B;2019年06期
17 Brian L Erstad;;Designing drug regimens for special intensive care unit populations[J];World Journal of Critical Care Medicine;2015年02期
18 Abdollah Ghasemi Pirbalouti;Maryam Mohammadi;;Phytochemical composition of the essential oil of different populations of Stachys lavandulifolia Vahl[J];Asian Pacific Journal of Tropical Biomedicine;2013年02期
19 Quan-Jiang Dong;Shu-Hui Zhan;Li-Li Wang;Yong-Ning Xin;Man Jiang;Shi-Ying Xuan;;Relatedness of Helicobacter pylori populations to gastric carcinogenesis[J];World Journal of Gastroenterology;2012年45期
20 许茜;陈菲;单锦城;张肇坚;陈彦;柯才焕;;AFLP analysis of genetic variation among three natural populations of horseshoe crab Tachypleus tridentatus along Chinese coast[J];Chinese Journal of Oceanology and Limnology;2011年02期
中国重要会议论文全文数据库 前10条
1 Lizhong Wang;Xiaotian Yao;Gang Chen;;Genome wide association study using direct-to-consumer genetic testing data and online survey approach in Han Chinese participants among WeGene users, a proof-of-concept study[A];2018中国遗传学会第十次全国会员代表大会暨学术讨论会论文摘要汇编[C];2018年
2 Shuanglin Gu;JianLi;;Construction of a public database for cancer-causing mutations in the Chinese population of HBV virus[A];2018中国遗传学会第十次全国会员代表大会暨学术讨论会论文摘要汇编[C];2018年
3 Hui Wang;Zhixin Chai;Qiumei Ji;Jinwei Xin;Chengfu Zhang;Jincheng Zhong;;A global analysis of CNVs in diverse yak populations using wholegenome resequencing[A];2018中国遗传学会第十次全国会员代表大会暨学术讨论会论文摘要汇编[C];2018年
4 Shuping Zhang;Wenhao Gan;Wenqiang Cui;Renqing Wang;;Adaptation and evolution of Rosa rugosa populations during invasion and decline[A];中国植物学会八十五周年学术年会论文摘要汇编(1993-2018)[C];2018年
5 Jian ZHAO;Wei LI;Dandan ZHANG;Xinping ZHU;Yongle CHEN;Kunci CHEN;;Geometric morphometric variations of the carapace variation among different populations of Mauremys mutica in China[A];2014年中国水产学会学术年会论文摘要集[C];2014年
6 丁晓帆;CHEN Wen-hui;ZHOU Shan-hong;LIU Xiao-mei;LIU Wen-bo;;Morphological and molecular identification of three populations of Hirschmanniella mucronata occurring on vegetables in Hainan Province[A];中国植物病理学会2015年学术年会论文集[C];2015年
7 ;Investigation of the prevalence and distributing feature of cardiovascular risk factors in Kazak populations in Ili of Xinjiang[A];第十三次全国心血管病学术会议论文集[C];2011年
8 ;Mapping of QTLs associated with grain type traits using three populations from a super hybrid rice Xieyou9308[A];2012年中国作物学会学术年会论文摘要集[C];2012年
9 ;THE EFFECTS OF HEAT AND COLD TREATMENTS ON THE ACTIVITIES OF ANTIOXIDATIVE ENZYMES IN THE MIGRATORY LOCUST, LOCUSTA MIGRATORIA (L.)[A];走向21世纪的中国昆虫学——中国昆虫学会2000年学术年会论文集[C];2000年
10 ;Estimation of genetic differentiation and gene flow of the populations of Pagrusomus major in China[A];甲壳动物学分会成立20周年暨刘瑞玉院士从事海洋科教工作55周年学术研讨会论文(摘要)集[C];2002年
中国博士学位论文全文数据库 前5条
1 郑勇奇;[D];The University of Edinburgh;1996年
2 Abdul Wahid Khanzai Baloch;[D];西北农林科技大学;2013年
3 Alireza Asem;中国孤雌卤虫的比较形态学与分子系统学研究[D];中国海洋大学;2015年
4 Seyed Benyamin Dalirsefat;中国地方绿壳蛋鸡蛋壳色素沉着的分析[D];中国农业大学;2015年
5 Fozia Khan;[D];中国海洋大学;2013年
中国硕士学位论文全文数据库 前2条
1 汉克;探索现代有竞争性的国际体制[D];浙江大学;2014年
2 陈小龙;福建省不同地点黄曲条跳甲的RAPD分析[D];福建农林大学;2003年
中国知网广告投放
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978