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Commensal bacterial expressing Blc~(E84) disrupts intestinal epithelial barrier and induces inflammation

Dayuan Zou  Di Chen  Jianfeng Lan  Yuanyuan Zhang  An Tang  Hongjuan Chen  Haoliang Yuan  Di Wu  Zan Huang  Peiliang Shi  Qin Chen  Dingyu Wang  Yufang Wang  Siyuan Hou  Yujie Zou  Jingwen Pei  Lina Zou  Jianan Ren  Zhaoyu Lin  Xiang Gao  
【摘要】:正Background: Alteration of commensal bacterial composition is associated with diarrhoea pathogenesis.However, few study to pin point the function of specific genes encoded by bacteria in regulating intestinal inflammation.Results: By screening 3,983 E. coli mutants, we found that absence of bacterial lipocalin (blc) activated innate immunity in C. elegans. We further identified a SNP in several diarrhoeagenic E. coli strains that encode BlcE84, different from the BlcG84 in non-pathogenic bacteria. Exposure to BlcE84 bacteria caused decrease of lysophosphatidylethanolamine (LPE) in intestine, leading to gut epithelial barrier disruption and

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