p53-induced miR-34a contributes liver regeneration termination via regulation of INHBB and MET

【摘要】：正Liver regeneration after partial hepatactomy is a well orchestrated process that ceases when liver regains its original mass.The mechanisms of the termination of regeneration are still uncertain.Recent studies show that microRNAs(miRNAs),which commonly mediate posttranscriptional gene silencing,may be involved in LR.Here in this study,we report that miR-34a is significantly induced after partial hepatactomy.Introduction of miR-34a in BRL- 3A cells could inhibit cell proliferation,and down-regulate