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《第十三届全国免疫学学术大会摘要汇编》2018年
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Fates of CD8~+ T cells in Tumor Microenvironment

Resegofetse Maimela Nomathamsanqa  Shasha Liu  Yi Zhang  
【摘要】:Studies have reported a positive correlation between elevated CD8~+ T cells in the tumor microenvironment(TME) and good prognosis in cancer.However, the mechanisms linking T cell tumor-infiltration and tumor rejection are yet to be fully understood.The cells and factors of the TME facilitate tumor development in various ways.CD8~+ T cell function is influenced by a number of factors, including CD8~+ T cell trafficking and localization into tumor sites; as well as CD8~+ T cell growth and differentiation.This review highlights recent literature as well as currently evolving concepts regarding the fates of CD8~+ T cells in the TME from three different aspects CD8~+ T cell trafficking, differentiation and function.A thorough understanding of factors contributing to the fates of CD8~+ T cells will allow researchers to develop new strategies and improve on already existing strategies to facilitate CD8~+ T cell mediated anti-tumor function, impede T cell dysfunction and modulate the TME into a less immunosuppressive TME.
【作者单位】:The First Affiliated Hospital of Zhengzhou University
【分类号】:R730.3

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