Clinical Significance of Detecting HLA-DR, 14-3-3ηProtein, D-dimer in the Diagnosis of Rheumatoid Arthritis

【摘要】：Aim: To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis(RA).Methods: 128 RA patients,174 Non-RA patients and 80 healthy controls were enrolled.HLA-DR4,HLA-DR53 were detected by PCR-SSP method, 14-3-3η protein, anti-CCP, anti-Sa detected by ELISA, DD was detected by latex immunoturbidimetric assay.Results: The positive rates of HLA-DR4,HLA-DR53,14-3-3η protein, anti-CCP, anti-Sa were obviously higher in RA group(43.8%, 38.3%, 51.6%, 80%, 40.6% respectively); anti-CCP was of highest sensitivity(79.68%), highest specificity(97.5%) and Youden index(0.77); The AUC of 14-3-3η protein, DD, anti-CCP, anti-Sa were 0.813,0.859,0.930,0.861, respectively.Conclusion: All biomarkers were strongly correlated risk factors for RA, the combination of multiple biomarkers might be of help for diagnostic and therapeutic strategies in RA of recent onset.