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《第十三届全国免疫学学术大会摘要汇编》2018年
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Identification of CD163 as a novel immunotherapy target in glioma via large-scale analysis

Shasha Liu  Chaoqi Zhang  Resegofetse Maimela Nomathamsanqa  Zhen Zhang  Yu Ping  Lan Huang  Yi Zhang  
【摘要】:Background: The expression of CD163 in glioma and its involved function are not fully understood.We characterize the molecular and clinical features of CD163 in glioma in a large-scale study.Methods: 1323 glioma samples from Chinese Glioma Genome Atlas(CGGA) dataset, and 697 glioma samples from The Cancer Genome Atlas(TCGA) dataset were gathered into our research.The statistical analysis and graphical work was mainly realized by R language.Results: CD163 expression positively associated with the grade of malignancy of glioma.Consistently, CD163 expression was up-regulated in IDH wild-type glioma and mesenchymal subtype.Gene ontology analysis suggested that CD163 related genes were more involved in immune response and angiogenesis in glioma.Moreover, CD163 showed a positive relationship with stromal and immune cell populations.Kaplan-Meier curves analysis revealed that higher CD163 expression indicated significantly poor survival in glioma and GBM.Pearson correlation analysis revealed that CD163 was robustly associated with the immune checkpoints and the other macrophage markers.Conclusion: CD163 predicts the poor prognosis in glioma patients.Additionally, coordination with CD163 and immune checkpoints may impair the angiogenesis and reverse the dysfunctional phenotype of T cells.These findings suggest that CD163 may be a promising target for immunotherapeutic strategies.
【作者单位】:The First Affiliated Hospital of Zhengzhou University
【分类号】:R739.4

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