收藏本站
《第十三届全国免疫学学术大会分会场交流报告》2018年
收藏 | 手机打开
二维码
手机客户端打开本文

Seeking “protective” and “harmful” immune genes during chronic HIV-1 infection by transcriptome analysis

Lingyan Zhu  Chao Qiu  Chenli Qiu  Ying Wang  Yuan Dong  Linxia Zhang  Weihui Fu  Jun Wei  Xiaoyan Zhang  Jianqing Xu  
【摘要】:Human immunodeficiency virus(HIV)-infected individuals exhibit remarkable transcriptomic variation. Transcriptome analyses of antiretroviral therapy(ART)-free chronically infected HIV-1 patients with different clinical outcomes are likely to aid the development of vaccine and immune therapies. Here, we performed microarray analyses on whole-blood derived RNA from 89 ART-free HIV-1-infected individuals from two cohorts. The differentially expressed genes were analyzed between long-term non-progressors, viremic non-progressors and typical progressors, and between elite controllers and non-elite controllers among the long-term non-progressors. Several genes related to T-cell growth, proliferation and differentiation and antiapoptosis were upregulated, whereas interferon-stimulated genes and inflammatory genes were significantly downregulated in long-term non-progressors and viremic non-progressors. The observations above were further confirmed in the set of 261 genes that correlated with disease progression during a 5-year follow-up, which included 51 genes significantly associated with slower disease progression, and 210 genes associated with aggressive disease progression. Overall, our data suggest that it is vital to maintain the homeostasis of the immune system when mounting antiviral immune responses. Immune therapeutics able to reconstruct immune homeostasis are likely to be required for immune reconstitution in the context of ART, such as the administration of interleukin-7, healthy allogenic CD4~+ T cells(providing CD4~+ T-cell growth factors), or Tregs.

手机知网App
【相似文献】
中国期刊全文数据库 前10条
1 Mostafa Nokta;;Improving Acquired Immunodeficiency Syndrome Related Cancer Outcomes through International Collaboration[J];Chinese Journal of Integrative Medicine;2011年05期
2 Inês Araújo;Cristina Enjuanes-Grau;Carmen Jimenez Lopez-Guarch;Dariusz Narankiewicz;Maria J Ruiz-Cano;Teresa Velazquez-Martin;Juan Delgado;Pilar Escribano;;Pulmonary arterial hypertension related to human immunodeficiency virus infection:A case series[J];World Journal of Cardiology;2014年06期
3 WANG Xiao-dan;HAO Ji-fu;CHEN Wei;WANG Hao;WANG De-cai;ZHANG Han-ting;;Preparation and evaluation of silymarin nanosuspensions for protective effects on stress-induced liver injury[J];中国药理学与毒理学杂志;2017年05期
4 ;Discharge characteristics of protective LaB_6 thin films in an AC plasma display panel[J];Chinese Science Bulletin;2012年20期
5 ;Numerical simulation of protection range in exploiting the upper protective layer with a bow pseudo-incline technique[J];Mining Science and Technology;2009年01期
6 尚海平;徐秋霞;;Two-step Ni silicide process and influence of protective N_2 gas[J];半导体学报;2009年09期
7 ;Experimental research on methane control of mining upper protective layers[J];Engineering Sciences;2009年03期
8 ;Hypoxia inducible factor-1α mediates protective effects of ischemic preconditioning on ECV-304 endothelial cells[J];World Journal of Gastroenterology;2007年16期
9 ;Effect of SiC whiskers on the oxidation protective properties of SiC coatings for carbon/carbon composites[J];Rare Metals;2006年01期
10 周进,王君;The protective effect of subhypothermia on brain of patient with ischemic cerebrovascular disease on different time[J];中国临床康复;2003年01期
中国重要会议论文全文数据库 前10条
1 Lingyan Zhu;Chao Qiu;Chenli Qiu;Ying Wang;Yuan Dong;Linxia Zhang;Weihui Fu;Jun Wei;Xiaoyan Zhang;Jianqing Xu;;Seeking “protective” and “harmful” immune genes during chronic HIV-1 infection by transcriptome analysis[A];第十三届全国免疫学学术大会分会场交流报告[C];2018年
2 Jing Wang;Huaide Liu;Weihua Jin;Hong Zhang;Quanbin Zhang;;Structure-activity relationship of sulfated hetero-polysaccharides and sulfated galactofucan polysaccharides on protective effect of dopaminergic neuron in vivo and in vitro[A];第十二届海洋药物学术年会会刊[C];2015年
3 EMK Lui;L.Pereira;J.Ma;Q Zhang;T.Fatima;S.Lee;I Welch;;Cyto-protective Effects of Extracts of Panax Quinquefolius[A];第十四届全国中药和天然药物学术研讨会论文摘要[C];2014年
4 Ran Joo Choi;Xue Meng;Xiaohui Zheng;Tai-Ping Fan;;The Vaso-and Neuro-protective Activities of Medicinal Herbs for Alzheimer's Disease[A];第十四届全国中药和天然药物学术研讨会论文摘要[C];2014年
5 Songxia Li;Chunchen Wu;Liang Cao;Hui Wang;Kaitao Zhao;Yongxuan Yao;Mengji Lu;Xinwen Chen;;The Impact of Amino Acid Substitutions in HBsAg on the Biological Characteristic of HBV in vivo[A];2013年湖北省暨武汉微生物学会会员代表大会暨学术年会论文摘要集[C];2013年
6 ;The study of protective effects and mechanisms of rofecoxib on focal cerebral ischemia-reperfusion injury in rats[A];第十一届全国神经药理学术会议论文摘要集[C];2004年
7 ;Salvianolic Acid B induces GRP7/8 in human endothelial cells:another protective mechanism against oxidative stress-induced cellular damage[A];第六届海峡两岸心血管科学研讨会论文摘要集[C];2007年
8 ;Acute neurovascular unit protective action of pinocembrin against permanent cerebral ischemia in rats[A];药学发展前沿论坛及药理学博士论坛论文集[C];2008年
9 Zi-Yu Chang;Tzung-Yan Lee;Tse-Hung Huang;Chorng-Kai Wen;Rong-Nan Chien;Hen-Hong Chang;;Hepato-protective Effects of Ger-Gen-Chyn-Lian-Tang in Thioacetamide-induced Liver Fibrosis in Mice[A];第十四届全国中药和天然药物学术研讨会论文摘要[C];2014年
10 Hua Guan;Man Song;Yu Wang;Xiaodi Wang;Pingkun Zhou;;The protective effects of syringic acid on radiation injury of mice bone marrow[A];中国毒理学会第四届中青年学者科技论坛论文集[C];2014年
中国重要报纸全文数据库 前3条
1 记者 王丹阳;Shiatzy Chen联袂Elite World培育国际超模[N];中国纺织报;2009年
2 本报记者 管晓星;关于职业模特的热点话题[N];中国服饰报;2008年
3 艾美;美国Nylstar开发两种新纤维[N];中国纺织报;2002年
中国博士学位论文全文数据库 前1条
1 罗杰(Robert Chepkech Kipnusu);员工援助计划中的求助意愿及社会公理的预测作用[D];华中师范大学;2014年
中国硕士学位论文全文数据库 前5条
1 Patrick Tan;[D];山东大学;2017年
2 王瑾;非英语专业大学生使用话语标记语and的研究[D];武汉大学;2005年
3 洪丽;论话语标记语and的语用功能[D];安徽大学;2012年
4 喻晓倩;情绪对消费者媒体选择多样化寻求行为影响的实证研究[D];西南交通大学;2011年
5 魏文杰;基于语料库的中国英语学习者和英语本族者口语话语标记语and的使用情况对比分析[D];山东师范大学;2016年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026