收藏本站
收藏 | 手机打开
二维码
手机客户端打开本文

Essential role of hMASP-2 on the granuloma formation in animal model of tuberculosis

Ma Xingming  Xu Xiaoying  Luo Yanping  Zhang Lifeng  Wang Jingqiu  
【摘要】:Tuberculosis is a chronic infectious disease,which caused by Mycobacterium tuberculosis.It typically affects the functions of the lung and causes high morbidity and mortality rates worldwide.The formation and maintenance of granuloma are central to the development of the pathology of tuberculosis in murine models and human.MASP-2(MBL-associated serine protease-2) is an executioner enzyme,which plays an essential role in the activation of complment lectin pathway.We have previously studies the effects of human MASP-2(hMASP-2) on liquefaction and ulceration using a rabbit-skin model of BCG.We found that the hMASP-2 induced a dual effect in BCG-infected rabbit skin models,which promotes both the progress of lesions and reduces the survival of the mycobacteria within them.However,we used mouse model by intranasal administration of BCG to mice.Then recombinant adenovirus of hMASP-2 were applied to the BALB/c mice by intranasal administration.We found that the hMASP-2 increased the survival rate of infected mice and decreased the bacteria loads in lung tissue.hMASP-2 also displayed a protective efficacy in BCG-infected mice,which promoted the activation and recruitment of macrophages and lymphocytes to the granuloma,and induced the secretion of CCL12 and Th1 type cytokines.The findings provided an evidence that hMASP-2 may be as a newly immunomodulatory in targeting granuloma formation,which displayed a potential protective role in control of tuberculosis.

知网文化
【相似文献】
中国期刊全文数据库 前20条
1 ;Liver inflammatory pseudotumor or parasitic granuloma?[J];World Journal of Gastroenterology;2000年03期
2 Borislav Spajic;Hrvoje Cupic;Goran Stimac;Ivica Brigic;Bozo Kruslin;Ognjen Kraus;;Cholesterol granuloma of the right epididymis mimicking an acute scrotum[J];Asian Journal of Andrology;2006年06期
3 Tamás Molnár;László Tiszlavicz;Csaba Gyulai;Ferenc Nagy;János Lonovics;;Clinical significance of granuloma in Crohn's disease[J];World Journal of Gastroenterology;2005年20期
4 Guo-Dong Shan;Zong-Pin Chen;Yong-Sheng Xu;Xiao-Qin Liu;Yuan Gao;Feng-Ling Hu;Ying Fang;Cheng-Fu Xu;Guo-Qiang Xu;;Gastric foreign body granuloma caused by an embedded fishbone:A case report[J];World Journal of Gastroenterology;2014年12期
5 Yujo Kawashita;Yukio Kamohara;Junichiro Furui;Fumihiko Fujita;Shungo Miyamoto;Mitsuhisa Takatsuki;Kuniko Abe;Tomayoshi Hayashi;Yasuharu Ohno;Takashi Kanematsu;;Destructive granuloma derived from a liver cyst: A case report[J];World Journal of Gastroenterology;2006年11期
6 王冠庭;沈捷;王成;鲍绍芳;唐振铎;;致死性中线肉芽肿8例误诊分析[J];上海医学;1990年07期
7 ;Pathogen characteristics and its sensitivity against antimicrobial agents in fatal bacterial granuloma after eyelid trauma in vitro[J];International Journal of Ophthalmology(English Edition);2011年04期
8 Anosike;Chiuma Assumpta;Onyechi Obidoa;Lawrence U S Ezeanyika;;The anti-inflammatory activity of garden egg(Solanuni aethiopicum) on egg albumin-induced oedema and granuloma tissue formation in rats[J];Asian Pacific Journal of Tropical Medicine;2012年01期
9 刘红刚,郑麟蕃,刘宏伟;SPIROCHETES—— THE POSSIBLE ETIOLOGICAL FACTOR OF THE CHEILITIS GRANULOMATOSA[J];Chinese Medical Sciences Journal;2001年01期
10 罗凌惠 ,龚树生 ,白广平 ,汪吉宝;A Retrospective Study on Cholesteatoma Otitis Media Coexisting with Cholesterol Granuloma[J];Journal of Huazhong University of Science and Technology(Med;2002年02期
11 ;Percutaneous Puncture Biopsy and Treatment Using Lo-cal Injection of Prednisolone for Solitary Esosinophilic Granuloma of the Skull.[J];Chinese Medical Journal;1995年09期
12 Drew BETHUNE;Daria MANOS;Annette FOYLE;Harry HENTELEFF;Michael JOHNSTON;Yannick CARTIER;;肺玻璃样变肉芽肿病(英文)[J];北京大学学报(医学版);2009年04期
13 ;ALLERGY AND IMMUNOLOGY[J];China Medical Abstracts(Internal Medicine);1999年02期
14 ;Endoscopic findings and pathologic characteristics of gastric eosinophilic granuloma:A report of 18 patients[J];World Journal of Gastroenterology;2006年46期
15 Shenoy Smita;Shwetha K;Prabhu K;Maradi R;Bairy KL;Shanbhag T;;Evaluation of antiinflammatory activity of Tephrosia purpurea in rats[J];Asian Pacific Journal of Tropical Medicine;2010年03期
16 罗本涛;易祥华;罗本芳;芮炜玮;方建萍;朱旭友;朱美芳;;Clinicopathologic and ultrastructural observation of primary pulmonary cryptococcosis:a study of 37 cases[J];China Medical Abstracts(Surgery);2010年01期
17 ;Association between tuberculosis and polymorphism of HLA-BF,C4A,and C4B genes[J];中国输血杂志;2001年S1期
18 余日胜 ,刘奕青;Gallbladder tuberculosis:case report[J];Chinese Medical Journal;2002年08期
19 邵长周,瞿介明,何礼贤;A comparative study of clinical manifestations caused by tuberculosis in immunocompromised and non-immunocompromised patients[J];Chinese Medical Journal;2003年11期
20 ;Lung infection[J];China Medical Abstracts(Internal Medicine);2005年02期
中国重要会议论文全文数据库 前10条
1 ;Foreign body granuloma reaction with the use of medical glue and literature review:2 case report[A];2013年浙江省肛肠外科学术年会暨结直肠疾病的微创及综合治疗新进展学习班论文汇编[C];2013年
2 ;Prostatic granuloma after intravesical insti1lation of BCG (Report of 1cases)[A];第十五届全国泌尿外科学术会议论文集[C];2008年
3 ;The clinical value of 3-dimensional reconstruction with spiral CT in the diagnosis of renal tuberculosis[A];第十五届全国泌尿外科学术会议论文集[C];2008年
4 ;Can Mycobacterium tuberculosis DNA be detected in plasma/serum samples from tuberculosis patients?[A];中华医学会第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议论文汇编[C];2011年
5 ;Two novel ways for Distinguishing sarcoidosis from sputum negative tuberculosis[A];中华医学会呼吸病学年会——2011(第十二次全国呼吸病学学术会议)论文汇编[C];2011年
6 Xiuying Pei;Shuya Zhang;Yan Li;;Associations between MCP-1,NRAMP1 and MBL SNPs and tuberculosis in haiyuan hui people[A];中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议摘要集[C];2010年
7 ;The perceptions and needs assessment of tuberculosis among the residents in rural China[A];华东地区第十次流行病学学术会议暨华东地区流行病学学术会议20周年庆典论文汇编[C];2010年
8 ;The establishment of rapidly detecting Mycobacterium tuberculosis drug-resistance by gene-chip and the rearch of detecting the drug-resistance of clinical Mycobacterium tuberculosis[A];华东六省一市生物化学与分子生物学会2003年学术交流会论文摘要集[C];2003年
9 ;Clinical application of bronchoscopy in diagnosis of tracheobronchial tuberculosis[A];第十七届中国内镜医师大会论文集[C];2007年
10 Lsamu Sugawara;;Cytokine network and tuberculosis[A];中华医学会第六届全国结核病学术大会论文汇编[C];2000年
中国博士学位论文全文数据库 前1条
1 吕亮东;Mycobacterium tuberculosis H37Ra毒力丢失机制[D];复旦大学;2010年
中国硕士学位论文全文数据库 前1条
1 陈广生;肺玻璃样变肉芽肿1例并文献复习[D];广西医科大学;2016年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978