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IL-33 deficiency exacerbated EAE via modulating T cells and glia cells

xiao yifan  Chen Huoying  Lai Lin  Xu Yong  Tan Zheng  Gong Feili  Zheng Fang  
【摘要】:Background:Interleukin(IL)-33 induces innate and adaptive immune responses and plays a protective role in many diseases including autoimmune diseases.IL-33 is expressed highly in CNS suggesting a potential role of IL-33 in CNS.It has been found that IL-33 and receptor ST2 were expressed in spinal cord and the blockage of the CNS-derived IL-33 exac-

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