AuNRs/mesoporous silica/hydroxyapatite nanoparticles with thermally responsive polymeric cap for multi-responsive drug delivery
【摘要】：Owing to their remarkable physicochemical properties, the smart drug delivery system(DDS) has attracted increasing attentions in biomedical area because it can deliver drug more precisely and intelligently. One such particular example of DDS was the development of so-called photo-triggered theranostic nano-platforms, which could realize detection, therapy, and even monitor simultaneously by assembling functional polymer onto one single nanovehicle. Anchoring functional polymers onto certain inorganic nano-platform has resulted in the design of "smarter" DDS with controllable drug release properties. In the present paper, a novel smart drug delivery carrier was fabricated by grafting poly(N-isopropyl acrylamide-co-acrylic acid)(P(NIPAM-AA), PNA) onto Au nanorods(AuNRs)/SiO_2/hydroxyapatite(HAP) nanoparticles, whereas a remote NIR light was used to activate the phase change and subsequent drug release of the nanoparticles. The hybrid nanoparticles displayed excellent biodegradability and biocompatibility due to the introduction of HAP. In vitro drug release results demonstrated that the hybrid nanoparticles exhibited temperature/pH/NIR multi-responsive drug release properties. P(NIPAM-AA) acted as a thermal-responsive gate to control the drug release of AuNRs/SiO_2/HAP nano-platforms. Moreover, the thermal-responsive polymeric cap endowed the nanoparticles with reversible on-off release properties when exposing the nanoparticles to NIR irradiation. The present paper provides a facile route to fabricate the smart core-shell nanovehicle by integrating thermal-responsive polymers with AuNRs/SiO_2/HAP matrix, which is highly attractive for the remote controllable drug delivery.